Colonic resection and anastomosis is one of the most common operations in gastrointestinal surgery, both in children and adults. Although these are safe operations, an anastomosis leakage is a frequent problem (1, 2). Age, condition of the patient, colonic flora, inflammation and surgical techniques are the most important factors affecting the outcome of these procedures (3, 4). The presence of peritonitis is a defining factor of anastomosis integrity.The cecal ligation and puncture (CLP) model was first defined by Hubbard et al. (5) in 1978 to induce peritonitis. Several studies suggest that in the presence of peritonitis, wound healing worsens and anastomotic leakage increases. To avoid these unwanted effects of peritonitis on wound healing and to increase anastomosis security, various methods and local or systemic agents are being investigated.Ozone is a three-oxygen molecule (O 3 ). Ozone therapy (OT) is systematically effective when pathological inflammatory and immunologic processes are activated. Among these conditions are wound healing, macular degeneration related to aging, and conditions that are ischemic or infectious.During OT, the gaseous mixture of oxygen and ozone exerts biological actions that may increase certain enzymes and cytokines. Ozone provides its protective effects via autacoids, cytokines, and growth factors. Recurrent OT corrects the disBackground: Ozone is a three-oxygen molecule (O3). Ozone therapy (OT) is systematically effective when pathological inflammatory and immunologic processes are activated. Among of these conditions are wound healing, macular degeneration related to aging, and conditions that are ischemic or infectious. Aims: The aim of this study was to determine the effects of OT on wound healing of intestinal anastomosis in the presence of peritonitis in a rat model. Study Design: Animal experimentation. Methods: A total of 40 Wistar albino rats were randomized into four groups (n=10) including: sham (S), peritonitis (P), ozone 0 (O0), and ozone 24 (O24). In group S, only cecal dissection was carried out. The S group had only a cecal dissection and intestinal anastomosis performed, but no peritonitis. In all other groups, cecal ligation and puncture (CLP) followed the cecal dissection to induce bacterial peritonitis. 24 h after puncture, a cecal resection and ileocolic anastomosis were performed. In group P, 24 h after CLP, a cecal resection and ileocolic anastomosis were performed and no ozone was administered. In group O0, immediately after the anastomosis, and in group O24, starting 24 hours after the anastomosis, an intraperitoneal 1 mg/ kg/day ozone administration was applied for seven days. On the seventh day the animals were sacrificed, the anastomotic bursting pressures (BP) and the hydroxyproline values of the anastomotic tissues were measured, and histopathologic examination of the anastomotic segment was carried out. Results: The highest BP was in group S, with 211±23.13 mmHg. The mean BP of group P was 141±56.25 mmHg, which was significantly lower than in t...
Dev hücreli granüloma paranazal sinüslerin nadir görülen bir tümö-rüdür. En sık genç hastalarda ortaya çıkar. İkinci sıklıkla yaşamın 4. dekatında pik yapabilir. En sık görülen lokalizasyonu premolar diş böl-gesidir. Mandibula, maksilla ve etmoid kemikte yerleşmeyi çok sever. Sekonder olarak orbita içine uzanır, propitozise sebep olur. Dev hücreli granüloma, genellikle bir travmayı takiben ortaya çıkmaktadır, lezyon reperasyonu kontrol edilemeyen bir kemik reaksiyonudur. Patolojik bulgu olarak, stromada spind benzeri hücrelerle karışan multinükleer dev hücrelere rastlanır. Değişik vaskülarite, hemoraji ve enflamasyon dikkati çeker. Biz de travma sonrası gelişen sağ maksiller sinüs kaynaklı, sağ nazal kavitede alt konkayı süperomediale ekspanse ederek nazal kaviteye büyümüş dev hücreli reperatif granülom vakasını tartışmaya çalıştık.Anahtar Kelimeler: Granülom, dev hücre, reperatif, nazal kavite, paranazal sinüs Giant cell granuloma is a rare tumor of paranasal sinuses. Generally, it occurs at young ages, with a 4 th decade peak. It is mostly seen in the premolar teeth area. This tumor tends to locate at the mandibular, maxillary, and ethmoid sinuses. Giant cell granuloma generally occurs after a trauma. Reparation of the lesion is a bone reaction, which can not be controlled. As for pathologic findings, it is met with giant granuloma cells mixed up in cells, like stroma spind gland. Varied vascularity, hemorrhage, and inflammation draw attention. We try to discuss a case of giant cell reparative granuloma of the nasal cavity by expansing inferior concha to superomedial at the right nasal cavity that originated from the right maxillary sinus, growing after trauma.Key Words: Granuloma, giant cell, reparative, nasal cavity, paranasal sinuses GirişDev hücreli granüloma diğer ismi ile reperatif dev hücreli granüloma baş boyun bölgesinde değişik lokalizasyonlarda görülebilen benign karakterli nadir tümörlerdir. Maksilla ve mandibula yaygın olarak görüldüğü lokalizasyonlar olup, temporal kemik, oksipital kemik, orbita ve sinonazal traktus diğer görüldüğü yerlerdir (1). En sık 1. ve 2. dekatta ortaya çıkar. Lezyonun lokalizasyonuna bağlı olarak ağrı, yüzde şişlik, burun tıkanıklığı, burun kanaması ve görme problemlerine neden olabilir. Benign karakterli bir tümör olmakla birlikte, lokal destrüksiyon yapabilir ve agresif seyredebilir. Sinonazal traktus yerleşimli dev hücreli reperatif granülomların radyolojik değerlen-dirilmesinde, kemik ekspansiyonu ve incelmesi ile birlikte sinüslerde opasifiye kitle dikkat çeker. Bilgisayarlı tomografide (BT) yumuşak doku kalsifikasyonları gözlenebilir ve diğer osteojenik lezyonlara benzetilebilir (1, 2). Dev hücreli reperatif granülom histopatolojisinde, lezyonun çevresi skuamöz epitel ile çevrili olup, lezyon ile epitel arasında bağ dokusundan oluşan temiz bir alan mevcuttur. Değişik derecede inflamasyon ve vaskülarizasyon gösterebilir. Tipik olarak ovoid ve fusiform şekilli mezenkimal hücreler arasında çok çekirdekli dev hücreler görülür. Arada küçük alanlar halinde yeni kemik oluş...
Adversarial images are samples that are intentionally modified to deceive machine learning systems. They are widely used in applications such as CAPTHAs to help distinguish legitimate human users from bots. However, the noise introduced during the adversarial image generation process degrades the perceptual quality and introduces artificial colors; making it also difficult for humans to classify images and recognize objects. In this paper, we propose a method to enhance the perceptual quality of these adversarial images. The proposed method is attack type agnostic and could be used in association with the existing attacks in the literature. Our experiments show that the generated adversarial images have lower Euclidean distances to their originals while maintaining the same adversarial attack performance. Distances are reduced by 5.88% to 41.27% with an average reduction of 22% over the different attack and network types.
Granüler hücreli tümör (GHT), nadir görülen mezenkimal bir neoplazmdır. Çoğunlukla baş-boyun bölgesinde özellikle de dilde yerleşim göstermekte olup nadiren rekürrens gösterir. Bu çalışmada 6 ay içerisinde nüks gösteren bir GHT olgusu sunduk. 53 yaşında erkek hasta, sırtta yavaş büyüyen kitle GHT olarak rapor edildi, tümörde pleomorfizim, mitoz, nekroz ve atipi mevcut değildi. Olgunun 6 aylık takibinde lezyon nüks etti ve tekrar eksize edildi. Nüks lezyon eskisi ile aynı özellikleri göstermekte idi ancak daha düzensiz sınırlı ve etraf dokulara infiltratif görünümde idi, ayrıca yüksek Ki-67 oranına (%10) sahipti. Belirsiz davranışlı kabul edilen olgumuzun 3 yıllık takiplerinde lokaluzak yayılım saptanmadı. GHT genellikle benign gidişli stromal bir tümör olmakla beraber öngörülemeyen agresiv davranma potansiyeli nedeniyle tüm olgular takip altında tutulmalıdır.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.