An unprecedented Ru(II)-catalyzed C-H activation and annulation reaction, which proceeds via C-C triple bond cleavage, is reported. This reaction of 2-phenyldihydrophthalazinediones with alkynes, which works most efficiently in the presence of bidented ligand 1,3-bis(diphenylphosphino)propane, affords good yields of substituted quinazolines.
Co(ii) complexes having an anthracene-based curcuminoid ligand display moderate binding propensity towards calf thymus DNA and human serum albumin and remarkable photo-cytotoxicity in HeLa, MCF-7 and MDA-MB-231 cells on excitation with visible light.
A cascade, Ru(ii)-catalyzed annulative transformation of phenylindazolones and alkynes into indolo[1,2-a]quinazolinones and indazolo[1,2-a]indazolones is reported.
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