A correlation of structure with estrogenic activity of plant phenolics (including coumestrol, isoflavones and desoxybenzoins) and certain synthetic estrogens has been made. Pertinent compounds were re-evaluated under standardized conditions. The most active of the compounds synthesized for this study was 7,4'diacetoxy-2-methyl-4-ethyl-A3-isoflaven.Current interest in this laboratory regarding the biological activity of coumestrol and other plant estrogens as compared to the growthpromoting effect of diethylstilbestrol has led to a continued2 investigation of the structure-activity relationship of certain coumarins, isoflavones, desoxybenzoins and related compounds. In addition, the estrogenic activity of representative samples from these different classes of compounds has been re-evaluated and these activities correlated under identical bioassay conditions.The activity of the compounds was evaluated by linearly plotting the mean mouse uterine weight for a series of doses. The dose level recorded in the Tables represents the quantity of material fed to produce a 25-mg. uterine response as compare to a uterine weight of 10 mg. for untreated animals.3a,bCertain derivatives of diethylstilbestrol and coumestrol have been bioassayed for comparison purposes and the values included in Tables I and II. Some isoflavens (Table III) are extremely potent estrogens4
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