Objectives: This study aimed to assess the magnitude of self-medication, symptoms or diseases leading to self-medication drugs used and their pharmacological classes among pregnant women. Patients and Methods: This was a cross sectional study which was conducted using face to face interview with 350 pregnant women at government hospitals and health centres. Structured questionnaire were used. Self-medication was defined as treatment, based on symptoms, without prescription and without medical consultation during the last pregnancy. Data were analysed using Epi-info 7.2.0.1 software. Results: Among 350 pregnant women, 41, 14% reported self-medication. Proportion of women with self-medication schooled pregnant was 97.22%, 68.75% professional activity and 88.89% in couple. Mean age was 27±6.3 years. Frequency was 97.22% among educated women, 68.75% among employed women. Self-medication was due mainly for headache (42.22%), fever (17.36%), malaria (13.88%) and urinary tract infections (8.33%). The drugs and therapeutic classes were paracetamol (analgesic) with 70% of cases, Diclofenac and ibuprofen (non-steroidal anti-inflammatory drugs) with 18.75%, chloramphenicol (antibiotics) with 18.75%. The major sources of drugs included, market (55.56% %) and pharmacies 30.88%. The main reason for choice of drugs for self-medication was "safe treatment ". Conclusion: Self-medication is common among pregnant women in Brazzaville. Our findings highlight need for prevention interventions such as sensibilisation during prenatal consultations on the risks related to the consumption of drugs without medical prescriptions and governmental actions in order to more regulate citizens access to drugs. Further studies on adverse effects are urgently needed. .