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OBJECTIVES:The present study was designed to evaluate the association of lipid profile in pre-eclampsia and if there is any change in lipid profiles in pre-eclampsic mother as compared to no pregnant woman and normotensive pregnant mother. METHODS: This case-control study was carried out in the department of Obstetrics and gynaecology of Burdwan medical college, Burdwan from 1 st June 2012 to 31 st May 2013.Total 180 patient were evaluated of which 60 were non-pregnant normotensive,60 were pregnant normotensive and 60 were pre-eclamptic mother. Age group was in between 19-35 years. In case of pregnancy gestational age was in between 32 to 36 weeks. Patients with pre-existing hypertension were excluded. Serum lipid profile (total cholesterol, triglycerides, HDL-cholesterol VLDL and LDL cholesterol) of one hundred and eighty women with Pre-eclampsia (n=60), normotensive non pregnant women (n=60) and normotensive pregnant woman (n=60) were monitored .Comparison is drawn and analysed by using chi-square test (SPSS 18 software). RESULTS: In preeclampsia there is significant decrease of High density lipoprotein(HDL) and significantly increase of Low density lipoprotein(LDL),Very low density lipoprotein (VLDL) and Triglycerides concentration seen compared to non pregnant normotensive and pregnant normotensive subjects. CONCLUSION: Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia and Eclampsia. Increased triglycerides, total cholesterol, LDL, VLDL levels along with decreased HDL-cholesterol levels and high blood pressure are associated with development of preeclampsia and eclampsia. This association may be significant in understanding the pathologic processes of preeclampsia and may help in developing strategies for prevention or early diagnosis of this disorder.

Background: Human papillomavirus (HPV) is one of the major infectious agents of cervical cancer. Papanicolaou (pap) smear study is generally carried out to screen the initial cervical condition and consequently specific PCR based study is carried out to recognize the different types of HPV. In the present study, we would like to screen the frequency of HPV infection in the women with normal and abnormal cervical discharges. Methods: In our study, 216 subjects were recruited. Cervical cytology was done by Pap smear test. Nested PCR was carried out using MY09/11 and GP 5+/6+ primers to screen HPV infection. Result and conclusion: A significant co-relation between HPV infection and early sexual intercourse was observed. We found a higher HPV prevalence in the age group below 29 years (35.48%). 85.71% SCC patients were positive for HPV infection, 80% HSIL patients were positive for HPV infection, 75% LSIL patients were positive for HPV infection; 66.7% ASCUS patients were positive for HPV infection. 50% ASC-H patients were positive for HPV infection. HPV positive was found in 22.22% of the subjects, among them 16.75% show normal cytology (NILM).

AimIn modern obstetrics, need of labor induction is increasing along with increased caesarean deliveries. Major contributions for these operative deliveries are due to induction failure. This demands a potent labor‐inducing agent. Dinoprostone gel is an established method but having some drawbacks. Misoprostol could be an effective alternative to Dinoprostone, but its fetal safety is not yet well established. This study aimed to evaluate the fetal safety of vaginal Misoprostol tablet by measuring fetal heart rate changes during induction of labor.MethodsThis was a single‐center randomized controlled trial incorporating 140 term women, equally randomized to get either tablet Misoprostol or Dinoprostone gel. Fetal heart rate patterns were compared in both the groups by continuous cardiotocographic tracing. All the data were analyzed on an intention‐to‐treat basis.ResultsThere were no statistically significant changes in fetal heart rate pattern in both Misoprostol and Dinoprostone groups. Vaginal deliveries were statistically higher in Misoprostol group. Neonatal parameters like 1 min Appearance, Pulse, Grimace, Activity, and Respiration score and neonatal intensive care unit admission were comparable, and there was no significant difference in terms of major adverse events and side effects.ConclusionsMisoprostol is a safe alternative to Dinoprostone gel for induction of labor and found to be more effective labor‐inducing agent. In the background of higher caesarean rate, vaginal Misoprostol can be a potential labor‐inducing agent especially in a resource poor setting.

This randomized controlled trial (RCT) was undertaken to evaluate the effect of vibroacoustic stimulation (VAS) on the fetal heart rate tracing, mode of delivery and perinatal outcomes, when cardiotocographs (CTG) showed non-reassuring features during labour. In this RCT, 60 women beyond 30 weeks' gestation in labour having non reassuring CTG for 20 min were recruited in either study group (VAS group) or control group (non-VAS group). Women in the study group received VAS for 3 sec up to 3 occasions at an interval of 1 to 3 min while the control group received no VAS. There were significant improvement of baseline variability and acceleration in both VAS and control group during second 20 min (P<0.001). Although these improvements were more evident in VAS group, the difference between the two groups were not statistically significant (P>0.05). However, in VAS group, there was 3 min less testing time required to achieve reassuring CTG features (2.6 versus 5.6 min), and a tendency to have less cesarean delivery (60% versus 55.2%; p>0.05). Perinatal outcomes were similar in both groups. There is a trend toward less number of caesarean section in VAS group, probably because of early and more acquisition of reassuring CTG features. Therefore, this study suggests that VAS is potentially beneficial in women with suspicious CTG. Considering the procedure simple, safe and less expensive, it would be prudent to use VAS during CTG monitoring, especially in low resource countries, where facilities for fetal blood sampling is not widely available.