No abstract

IntroductionOxygen is the most common drug used in critical care patients to correct episodes of hypoxaemia. The adoption of new technologies in clinical practice, such as closed-loop systems for an automatic oxygen titration, may improve outcomes and reduce the healthcare professionals’ workload at the bedside; however, certainty of the evidence regarding the safety and benefits still remains low. We aim to evaluate the effectiveness, efficacy and safety of the closed-loop oxygen control for patients with hypoxaemia during the hospitalisation period by conducting a systematic review and meta-analysis.Methods and analysisMEDLINE, CENTRAL, EMBASE, LILACS, CINAHL and LOVE evidence databases will be searched. Randomised controlled trials and cross-over studies investigating the PICO (Population, Intervention, Comparator and Outcome) framework will be included. The primary outcomes will be the time in the peripheral oxygen saturation target. Secondary outcomes will include time for oxygen weaning time; length of stay; costs; adverse events; mortality; healthcare professionals’ workload, and percentage of time with hypoxia and hyperoxia. Two reviewers will independently screen and extract data and perform quality assessment of included studies. The Cochrane risk of bias tool will be used to assess risk of bias. The RevMan V.5.4 software will be used for statistical analysis. Heterogeneity will be analysed using I2statistics. Mean difference or standardised mean difference with 95% CI and p value will be used to calculate treatment effect for outcome variables.Ethics and disseminationEthical approval is not required because this systematic review and meta-analysis is based on previously published data. Final results will be published in peer-reviewed journals and presented at relevant conferences and events.PROSPERO registration numberCRD42022306033.

Introduction: Obesity is determined by energy imbalance between consumed calories and spent calories. The projection is that by 2025, about 2.3 billion adults are overweight and over 700 million obese, being largely associated with an increase in the prevalence of chronic non-communicable diseases. Objectives: The objective of the study was to identify whether biological and social-behavioral factors are associated with the prevalence of overweight / obesity in a sample of young university students.        Method: The study was approved by the Research Ethics Committee of the Federal University of Amazonas. A cross-sectional study was carried out, in which 174 participants with an average age of 21 (± 4.3) years, from the Federal University of Amazonas, were evaluated. They were students of Physical Therapy and Physical Education Courses. A self-administered questionnaire was used, which included personal and behavioral data, anthropometric data and seated blood pressure measurements. The blood collection analyzed lipid profile, glycemia, glycated hemoglobin and insulin cytokines. The Poisson regression model was used, considering in the final model those variables with p <0.05. Results: The study showed that 42% (n = 73) of the individuals evaluated were overweight / obese. The variables significantly associated with overweight / obesity after Poisson analysis were elevated diastolic blood pressure, elevated hip circumference, high neck circumference, and alcohol consumption. Conclusion: It was observed in the study that the behavioral and anthropometric determinants were significantly associated with the increase in the prevalence of overweight / obesity in the sample evaluated. It should be noted that alcohol consumption, from one to five times a week, was significantly associated with the prevalence analyzed.