Abstract::
Hybridization is an important strategy to design molecules that can be effectively used to treat fatal diseases known to mankind. Molecular hybrids and their pharmacological investigations aided to discover several potent isatin (Indole 2, 3 dione) derivatives with anti-HIV, antimalarial, antitubercular, antibacterial, and anticancer activities. Indole‐2,3‐dione and their derivatives have diverse pharmacological properties and have a prominent role in the discovery of new drugs. To understand the various approaches in designing new molecules based on isatin nucleus analysis of various pharmacophore hybrids, spacers/linkers between pharmacophores and isatin for hybridization and their biological activities is important. This review discusses the progress in developing isatin hybrids as biologically effective agents, and their crucial aspects of design and structure-activity relationships.
Background::
Aloe vera is a traditionally used plant for medicinal purposes, mostly as a cosmetic. The Aloe vera gel/extract/juice is being used in hair care, moisturizing, cleansing, and thickening agent in formulations. The Aloe vera gel is rarely used on burns, wounds, infections, and gastric diseases.
Objectives::
To study the patents filed recently to understand the trend in the application of Aloe vera for therapeutic purposes.
Methods::
This patent review focuses on granted patents during the year 2013-till 2020. The patents were analyzed and their therapeutic use was studied to assess the recent trends in Aloe vera formulations.
Results::
Most of the patents of this article on skincare products and out of those maximum patents are on moisturizing compositions. Most of the patents are found in US jurisdiction and few in Europe and China. As there are certain restrictions on patenting inventions related to composition and natural products in various jurisdictions, patents are found in only a few jurisdictions.
Conclusion::
The trend of use of Aloe vera is still towards cosmetic products also the Aloe vera is used in oral care composition, deodorant compositions, anti-inflammatory composition, vitamin compositions, antibiotic compositions, etc.
Equimolar quantities of 5-Fluoroisatin (0.01 M) in 5 ml of warm ethanol and thiophene-2-ethylamine (0.01 M) were mixed. Two drops of acetic acid were added to the mixture and stirred at 500 Revolutions Per minute (RPM) for 6 hr. The resultant yellow solid was washed with ethanol and recrystallized from the chloroform-methanol mixture.
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