The chemical composition of the volatile extract (yield ≈ 0.13%, v/w) from the bark of Quercus leucotrichophora (Fagaceae) was analysed for the first time by GC-MS. Twenty-three constituents, amounting to 93.0% of the total detected contents of the volatile extract, were identified. The volatile extract contained approximately 86.36% monoterpenoids, 6.53% sesquiterpenoids and 0.11% aliphatic aldehydes. 1,8-Cineol (40.359%) followed by γ-terpinene (16.369%) were the major monoterpene constituents of the volatile extract. The residue of volatile extract (0.00025-250 µg mL(-1)) exhibited a potent antimicrobial activity against Streptococcus pyogenes ATCC 19615. This study concludes that residues of the volatile extract of Q. leucotrichophora could serve as an important bioresource for the extraction and isolation of monoterpenoids exhibiting antimicrobial activity, and thus has good potential for use in the pharmaceutical industry.
Present study involves the development of a polyherbal formulation by using four different herbs i.e. Chirata (Swertia chiratia), Haldi (Curcuma longa), Neem (Azadirachta indica), Gudmar (Gymnema sylvestre), Ashwagandha (Withania somnifera), Gokharu (Pedalium murex), Methi (Trigonella foenum-graecum), Jammun (Syzygium cumini), relating to antidiabetic activity. Freshly collected and authenticated herbs were characterized by studying its morphological and pharmacognostic character. Antidiabetic and antioxidant activity of the formulation was determined by in vitro haemoglobin glycosylation assay and H2O2 radical scavenging method respectively. In the above study it was found that ethanolic extract of polyherbal formulation possess promising antidiabetic and antioxidant activity which can be consider for further biological investigation.
Keywords: polyherbal formulation, Swertia chiratia, Curcuma longa, Azadirachta indica, Gymnema sylvestre, Withania somnifera, Pedalium murex, Trigonella foenum-graecum, Syzygium cumini
Nanoparticles can be synthesised using a variety of methods. These approaches, on the other hand, are connected with the development of undesired byproducts that are both harmful and expensive. As a result, several attempts are being undertaken to develop unique, cost-effective, safe, and dependable "green" techniques for producing desirable nanoparticles. To develop a novel, environment-friendly, economic, safe approach to the synthesis of gold nanoparticles via the biological entity. Addition of aqueous gold chloride solution to the microwave-exposed aqueous extracellular Cassia tora leaf extract yielded poly shaped gold nanoparticles. The UV-vis. spectroscopic investigations are led to notice and affirm the formation of nanoparticles. FTIR studies are performed to affirm the role of a biomolecule in stabilizing the nanoparticles. X-beam diffraction study is utilized to affirm the crystalline nature of nanoparticles. The elemental characterization of the samples is regulated by EDX studies. The size and morphology of the synthesized nanoparticles are explored using HR-TEM analysis and FESEM. It is seen that the flavonoids which are separated during microwave warming of extracellular solution of the cassia tora leaves are liable for the biosynthesis of gold nanoparticles. The nanoparticle was noted to be well dispersed and polyshaped with a 20-60 nm range. The leaf extract based preparation of AuNP is more gainful since leaf is used instead of microorganism as many of the issues like pathogenicity, procedural maintenance of hygiene of cell culture and labor efforts can be overcome. The presence of flavonoids in the leaf was discovered by the examination of produced nanoparticles, suggesting that they may have fulfilled both reduction and stabilisation activities. The presented approach can be inferred to be cost-effective, environmentally friendly, and capable of manufacturing nanoparticles with desired physical and pharmacological properties.
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