Background: Uterine fibroids or myomas or leiomyoma of uterus are the most common type of benign tumour of uterus and also most common pelvic tumour in women. Exact etiology is not known but the cause estimated to be is oestrogen and progesterone which proliferate tumour growth as fibroid rarely occur before menarche and reduces after menopause.Risk factors for developing fibroids are age, early age at menarche, reduced fertility, frequent alcohol and caffeine consumption, obesity, hypertension, diabetes mellitus, and previous pelvic inflammatory disease.  Objective of the research was to study the epidemiological factors associated with uterine fibroids.Methods: This present cross sectional descriptive observational study carried at Vilasrao Deshmukh Government Medical College (VDGMC), Latur from October 2019 to October 2021 among all cases of fibroid admitted at our tertiary care hospital. Data was analysed by using statistical package for the social sciences (SPSS) 24.0 version IBM United States of America (USA) and results are mentioned in percentages.Results: Out of 166 women, majority were from 31-40 years age group i.e. 58 (34.9%). Majority of the women were from urban area i.e. 57.2%. 13.2% were nullipara and 14.5% were multipara and grand multipara. 19.3% women were not practicing any contraceptive method. Abdominal lump complained by 41%, abnormal uterine bleeding 24.1%, metrorrhagia in 21.7%. Ultrasonography (USG) findings of the study population revealed submucosal fibroids in 64(38.6%), and intramural fibroids in 32 (19.3%).Conclusions: Incidence of fibroids is most common in 31-40 years of age i.e. 34.9%. Commonly observed symptom was abdominal lump (41%) and abnormal uterine bleeding (24.1%). Prevalence of submucosal fibroids was 38.6%, intramural fibroids 19.3%, submucosal polyp 14.5%, seedling fibroid 13.9% and subserosal fibroid 10.2%.

Background: This study was conducted to evaluate the effectiveness and side effects of Prostaglandins (vaginal misoprostol) in the termination of second and third trimester pregnancies complicated with intrauterine fetal death. Methods: This study was carried out on 100 women with intrauterine fetal demise in second and third trimester pregnancies collected from Government Medical college and Hospital during the period October 2014 to October 2016. Results: By the application of 25µg of misoprostol in the posterior fornix of vagina every 4 hourly over 24 hours. The progress, adverse effects and outcomes were assesed. The success rate was 92.76% and 64.52% in women with third and second trimesters respectively. The mean induction delivery interval was 15.67±9.64 and 24.94±8.23 for women with third and second trimesters respectively. The induction delivery interval correlated negatively with the duration of gestation. The mean value of total required dose was 192.42±128.99 and 361.29±139.92 for women with third and second trimesters respectively. Conclusions: Low dose misoprostol appears to be safe, effective, practical and inexpensive method for termination of third trimester pregnancies compared to second trimester complicated with intauterine fetal death and its effects increases with duration of gestation.

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Background: In India, preeclampsia and other hypertensive disorders of pregnancy are still one of the leading causes of adverse perinatal outcome.Methods: The observation descriptive study of preeclampsia with predetermined sample size of 195 was conducted at department of obstetrics and gynaecology at Government Medical College of Latur, over a time period of six month from March 2021 to August 2021. Findings are compared in frequency percentage values with the perinatal outcome of normotensive group from other study.Results: The prevalence of preeclampsia in our study was 4.1%. LBW found in preeclampsia group 32.3% versus 15% in normotensive group. Prematurity accounts for preeclampsia group 18.4% vs. 9% in normotensive group. Perinatal mortality rate is found to be 8.7 % vs. 2% in preeclampsia group vs. normotensive group respectively. Low APGAR score and NICU admission rate account for 14.8% vs. 13% and 16.4% vs. 11% respectively in preeclmpsia and normotensive group. Both FGR and oligohydroamnious accounts for 15.8% in preeclmpsia group. Important predictors of unfavourable perinatal outcome with p value significant (p<0.05), found in our study are severe and early onset of preeclampsia, severity of proteinuria and low birth weight.Conclusions: Adverse perinatal outcome in form of low birth weight, prematurity, fetal growth restriction and mortality is still high in preeclamsia patients than normotensive. So early diagnosis and treatment of preeclampsia is very crucial along with screening in high-risk patients to prevent unfavourable perinatal outcome.