Twenty-five patients with Type I (lepra) and Type 2 (ENL) reactions, were assayed for SIL-2R in serum-before and after treatment for their acute condition-and the results were compared with 10 normal healthy adults and 20 patients of leprosy per se. Classification of each subject into different leprosy groups, and into various types and subtypes of reactions, was done according to standard criteria, prior to inclusion into the study. Detailed statistical evaluation of the data revealed significantly higher levels of SIL-2R in all leprosy patients, as compared to normal controls, with higher levels in the multibacillary groups as compared to the paucibacillary group. SIL-2Rs appeared higher in Type I upgrading reaction than in other fo rms of reaction, though this was not statistically significant. There was no significant change in levels fo llowing treatment and clinical remiSSIOn. 'Soluble' interleukin-2 receptors (SIL-2R), are part of the alpha polypeptide subunit (55 Kd) with low affinity to IL-2, that are released from the cell membrane of activated immunocompetent cells under certain conditions, in vitro l and in vivo. 2 .3 The role of this molecule in modulation of immune mechanisms is still unsettled although its 'potential' in down-regulating immune activation is well recognized.4 In addition to malignancies,3 AIDS5 and autoimmune diseases, SIL-2R has been studied in leprosy patients per se with intriguing findings.6,7 The SIL-2R values were raised across the spectrum and did not vary significantly between the various clinical bacilliferous groups, while paucibacillary cases had significantly different values, fa lling somewhere between that of the normal healthy adults and the multibacillary clinical groups. However, in a few patients who were
Background: Psoriasis is associated with cause specific ocular involvement, uveitis being the most serious. Severity of skin disease, presence of arthritis and HLA B27 positivity may be associated with higher incidence of uveitis.
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