A study on sediment chemistry and water quality index of river Yamuna was conducted to understand the overall quality of river. Three sampling stations were selected: Station Y1 at the upstream of the river before the influx of effluents, Station Y2 at the point of influx and Station Y3 at 5 kilometres downstream from station Y2. The results showed the increasing values of pH, alkalinity, chloride and organic matter from station Y1 to Y2. Calculation of water quality index also categories station Y2 in bad or severely polluted zone.The correlation statisticsshowed the significant positive correlation between chloride and pH whereas significant negative correlation between organic matter and water quality index. The present work revealed the effect of Maskaranala's effluents on the overall chemistry of sediments of river Yamuna.