Gestational trophoblastic disease is a group of interrelated lesions arising from the trophoblastic epithelium of placenta after abnormal fertilization. It is a disease of women with pregnancy related tumors. Invasive mole, a common manifestation of gestational trophoblastic disease is characterized by villi accompanying trophoblastic overgrowths and invasion which penetrate deep into the myometrium sometimes involving peritoneum or vaginal vault. Here we present a case of persistent invasive mole in a patient who underwent dilation and curettage twice with persistent vaginal bleeding and elevated serum β-human Chorionic Gonadotropin levels. Investigations revealed enlarged uterus with adnexal pathology, Histopathological examination of Dilation and Curettage showed presence of villi and trophoblastic tissue, increased serum β-hCG levels. The patient is successfully treated and managed with methotrexate chemotherapy. This study is focused on the significance of follow-up of the patient as there are more chances of recurrence associated with gestational trophoblastic disease.
Background: Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare dermatological disorder characterized by fever and the sudden onset of a rash, which consists of multiple tender, red or bluish-red bumps or lesions. These lesions usually occur on the arms, legs, trunk, face, or neck. In some cases, additional systems of the body can become involved. Case Presentation: A 20-year-old male presented with chief complaints of fever, cough, and skin lesions. Laboratory investigations revealed an elevated erythrocyte sedimentation rate, C- reactive protein, neutrophils, and total leukocyte count. A skin biopsy was performed, and the patient was diagnosed with SS. Conclusion: The patient was treated with oral corticosteroids and other medications to alleviate his symptoms. He was discharged on a tapering dose of prednisolone, and follow-up after a month showed that he remained afebrile with no relapse of skin lesions.
Statistics is the discipline concerning collection, organizing, analyzing, interpretation and presentation of data as the basis for explanation, description and comparison. In clinical trials and in the drug development process, statistics play a key role, from trial design to protocol development. The credibility of a clinical trial can be upheld and cooperation between physicians and statisticians can be strengthened by providing a fundamental understanding of statistical issues. In any phase of clinical research, including trial design, development of procedures, data management and tracking, data processing, and reporting of clinical trials, biostatistics are involved. Statisticians also have roles in formulate hypothesis, develop statistical analysis plan (SAP), choosing the appropriate test, choose an apt sample size, data collection, perform the tests, generating TLGs (tables, listings, and graphs) and reporting the inferences. It is important that the rest of the research team recognizes the statistical approach suggested by the biostatistician, because statisticians can specialize in study designs, therapeutic areas and statistical methods.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.