Objective: Cryptococcal meningitis is an important cause of morbidity and mortality in HIV infected individuals. In the era of universal antiretroviral therapy incidence of immune reconstitution inflammatory syndrome (IRIS) related cryptococcal meningitis has increased. Detection of serum cryptococcal antigen in asymptomatic PLHIV (People Living With HIV) and pre-emptive treatment with fluconazole can decrease the burden of cryptococcal disease. We conducted this study to find the prevalence of asymptomatic cryptococcal antigenemia in India and its correlation with mortality in PLHIV. Method and material: This was a prospective observational study. HIV infected ART naïve patients with age of ≥ 18 years who had CD4 counts ≤ 100 /µL were included and serum cryptococcal antigen test was done. These patients were followed for six months to look for the development of Cryptococcal meningitis and mortality. Results: A total of 116 patients were analysed. Asymptomatic cryptococcal antigenemia was detected in 5.17% patients and it correlated with increased risk of cryptococcal meningitis and mortality on follow-up in PLHIV. Conclusion: Serum cryptococcal positivity is correlated with increased risk of Cryptococcal meningitis and mortality in PLHIV. We recommend the screening of asymptomatic PLHIV with CD4 ≤ 100/µL for serum cryptococcal antigen, so that pre-emptive treatment can be initiated to reduce morbidity and mortality.
Background: Stress hyperglycemia is a common phenomenon in patients presenting with acute myocardial infarction (MI). We aim to evaluate the association of stress hyperglycemia at the time of hospital presentation and adverse cardiac events in myocardial infarction during the course of hospital stay. Methods: Subjects with age ≥18 years with acute MI were recruited on hospital admission and categorized based on admission blood glucose (<180 and ≥180 mg/dl, 50 patients in each group). Both groups were compared for clinical outcomes, adverse cardiac events and mortality. We also compared the adverse cardiac outcomes based on HbA1c levels (<6% and ≥6%). Results: Patients with high blood glucose on admission (stress hyperglycemia) had significant increased incidences of severe heart failure (Killip class 3 and 4), arrythmias, cardiogenic shock and mortality (p value = 0.001, 0.004, 0.044, and 0.008 respectively). There was no significant association between adverse cardiac events and HbA1c levels (heart failure 18.8% vs. 25%, p value = 0.609 and mortality 16.7% vs. 17.3%, p value = 0.856). Conclusions: Stress hyperglycemia is significantly associated with adverse clinical outcomes in patients with MI irrespective of previous diabetic history or glycemic control. Clinicians should be vigilant for admission blood glucose while treating MI patients.
Background: The physiological changes in pregnancy may serve to protect the mother from the hazard of bleeding imposed by placentation and delivery, but they also carry the risk of an exaggerated response, localized or generalized, to coagulant stimuli. After correlating the trends of coagulation profile in all three trimesters of pregnancy with parameters [Body Mass Index (BMI), Glycemic status, Blood Pressure Status]; We can find out high risk pregnancies so that special attention can be given during pregnancy, labour and postpartum period. Material & Methods: A observational prospective analytic study done on 100 Pregnant ladies who were visited to routine antenatal clinic in the department of Obstetrics & Gynecological SMS Medical College and attached group of hospitals, on outdoor basis were selected in their first trimester (after 8 week gestation) in SMS medical college & attached group of hospitals during April 2017 to March 2018. The study protocol was approved by the Institutional Ethics Committee. All participants submitted informed consent before enrolment. After taking proper history, all the subjects underwent clinical examination comprising of general physical examination, assessment of vital parameters and systemic examination. Results: Our study that the mean age of study subjects was 26.46 ± 3.34 years. There was significant but weak positive correlation of D Dimer with BMI and Blood sugar in all trimesters of pregnancy. Significant correlation was found between APLA with DBP and MAP in 1st trimester of pregnancy. No correlation was found between APLA and other parameters in any trimester of pregnancy. Conclusion: We concluded that there were increased in FDP, D-Dimer, INR, APLA while platelets count, PT and aPTT were decreased. Further prospective study will be required to measure the outcome of pregnancy so we can define a high-risk pregnancy and those will get special attention in peripartum period. Keywords: Trimester, Pregnancy, D Dimer, BMI, Blood pressure, Correlation
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