Background: Splenomegaly is a matter of considerable clinical concern as spleen is not normally palpable. Splenomegaly is associated with large number of disorders including hematological, infectious, congestive states related to portal hypertension, lymphohematogenous disorders, immunological conditions, storage disorders and miscellaneous conditions. So, all the cases of splenomegaly should be thoroughly investigated to ascertain etiology. Splenomegaly can be an important diagnostic clue to existence of an underlying pathology. The aim and objective of present study was to find out relative frequency of clinical conditions associated with splenomegaly, to study clinic-hematological profile of splenomegaly and to find out the role of hematological investigations as a diagnostic tool in elucidating etiopathogenesis of splenomegaly.Methods: This was a cross sectional, observational study. Study was conducted on 135 pediatric as well as adult patients with splenomegaly admitted in medical ward, Government Medical College and tertiary care hospital Aurangabad, Maharashtra, India from December 2015 to October 2017. Hematological parameters of 135 cases of splenomegaly were analysed and correlated with clinical findings.Results: Study comprises 135 patients. Age range was 3 months to 78 years. Males (54.81%) were affected more commonly than females (45.19%). The most common presenting complaint was fever (59.26%) followed by generalized weakness (51.11%) and pallor (44.44%). Majority of cases (48.15%) had grade II splenomegaly. Splenomegaly was associated with hepatomegaly (60.74%) and lymphadenopathy (18.52%). The commonest cause of splenomegaly found was anemia (39.26%) followed by hematological malignancies (20.74%), congestive states (11.85%) and infections (11.85%). Hematological investigations revealed diagnosis in majority of cases (71%).Conclusions: Splenomegaly is an important clinical sign that must be investigated thoroughly as most of the common causes are treatable. Hematological causes outnumbered the non-hematological causes of splenomegaly. Hematological profile in cases of enlarged spleen are of utmost importance as a diagnostic or additional tool in elucidating the etiogenesis of splenomegaly.
The eye is a unique special sensory organ which exhibits diverse histologic structures. Clinical signs symptoms of ocular malignancies simulate more commonly occurring benign conditions which pose great difficulties both for treating clinicians even experienced pathologists. The present study is to evaluate the histomorphological spectrum of lesions of entire eyeball and ocular adnexa to compare our results with other studies.The present study included the 80 cases of tumours tumour like lesions in the eye its adnexa, in our institute during June 2013 to October 2015. All biopsies were embedded completely after thorough gross examination, resected specimens were noted for size, shape, consistency approximate section were taken. The enucleated eyeballs are sectioned according to stard protocols.In the present study, 80 cases of tumours and tumour like lesions in the eye its adnexa was carried. Out of these, eye lid was affected in 43 cases (53.75%), conjunctival cornea in16 cases (20%), intraocular in 17 cases (21.25%) orbit in 4 cases (05%).Among 80 cases maximum 44 cases (55%) were of malignant tumours followed by tumour like lesions 24 cases (30%) 12 cases (15%) of benign tumours. Histopathological examinations of orbital ocular lesions are absolutely mandatory for definitive diagnosis and further management. Illiterate patient take some home remedies, which leads to complications and loss of eyesight. So awareness is needed to ensure early presentation.
Childhood neoplasm exhibit unique features like they arise from embryonal cells are rapidly responsive to treatment. Survival rates in these patients have improved dramatically due to advancement in diagnostic modalities & aggressive combined management. [2] Common malignancies in pediatric age group include leukemia (30%), CNS tumors (20%), lymphomas (12%) followed by neuroblastoma, retinoblastoma, soft tissue tumors, renal neoplasms, bone tumors & neoplasms of gonads. [3] Male predominance is salient feature of many childhood tumors, genetic difference in immune function may be
Introduction: Sickle hemoglobin is highly prevalent among the tribal of central, southern, and western India which ranges from 10 to 23%. Sickle cell hemoglobinopathy a hereditary conditions that causes morbidity and mortality in school going children.
Aims and Objectives:To study the prevalence of sickle cell disorder among the students. Material and Methods: All the patient presented with sign and symptoms of anemia with suspicious of sickle cell disease and visiting various schools and colleges the samples were collected for CBC, peripheral smear, HPLC examination and reported. Results: Total 500 blood samples collected from school and college students for screening by HPLC and their hemoglobinopathy status. Showing prevalence of sickle cell anemia is 5.4%. Conclusions: It can be concluded that approaching community can be possible through school going adolescent for conducting surveillance of sickle cell anaemia. As it was small study, similar study of large size can be repeated by regular and planned visit to schools.
Introduction: Testicular cancers comprise 1% of all the male cancers worldwide. Various risk factors for development of testicular cancers include: a family history of testicular tumor in first degree relatives, infertility, cryptorchidism, Klinefelter's syndrome, 95% of testicular cancers arise from germ cells. Aims and objective: To study the relative incidence of testicular lesions among different age groups and to study the various histo-morpholoical patterns of testicular lesions. Materials and methods: All the patients those who are presented with testicular swelling and post orchiectomy specimens are included in this study. Results: Total testicular specimens received were 476, accounting for 1.49% of all surgical specimens. Of which 84 cases were diagnosed as tumors and tumor like lesions of testis accounting for 17.65%.
Conclusion:It is concluded that, despite new techniques in imaging and tumor marker assay the diagnosis of testicular lesions primarily dependent upon histo-pathological examination. Any testicular swelling must be evaluated thoroughly with clinic-pathological correlation to rule out malignancy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.