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In this research an attempt is made to study the effect of waste glass power in Concrete using waste glass, which is non biodegradable and not suitable to landfill. This study is carried out to use such waste materials into construction industries so that our environment is free to one of the major pollutant produced by the manufacturing industries. The main aim of this study is to utilization of waste glass power as a partial replacement of fine aggregate. In this study the aim is to determine the percentage of glass replacement, resulting in optimal compressive strength. Concrete nominal mix of M20 with different percentages of Glass power has been evaluated as per IS 2386(part IV) and IS 383. Waste glass powder was replace with fine aggregate in various percentages such as 5%,10%,15%,20%,25%,30%,35%,40%,45%, and 50%. Reference concrete mix is also made for comparative reasons.

BACKGROUND: Osteopetrosis is a collective term used for a pathological condition with defective function of osteoclasts presented with range of sclerosing bone diseases along with skeletal, renal, haematological & neurological manifestation. It may be autosomal recessive (ARO), autosomal dominant (ADO) and X-linked. It presents with hydrocephalus, short stature and anaemia, involvement of ocular nerve or facial nerve. Hypocalcemia, tetany, seizures & secondary hypoparathyroidism is known to occur. CASE REPORT: Two patients of osteopetrosis were posted for orthopaedic surgery. Both patients were operated under combined spinal epidural anaesthesia. 2ml of 0.5%Bupivacaine+30mcg clonidine was given intrathecally & epidural supplementation was given with Bupivacaine 3 cc increments after two segment regression of sensory level. Postoperative analgesia was provided by epidural Bupivacaine 0.125% along with Inj. Tramadol 50 mg on patient's request. CONCLUSION: Even if administration of anesthesia is a challenge in patients of Osteopetrosis, regional anaesthesia can be given safely with proper preoperative preparation & intraoperative care. KEY WORDS: osteopetrosis, femur fracture, combined spinal & epidural anaesthesia INTRODUCTION: Osteopetrosis is a collective term used for a pathological condition with defective function of osteoclasts presented with range of sclerosing bone diseases along with skeletal, renal, haematological & neurological manifestation. It is classified as Infantile malignant or (ARO), Intermediate type or (ARO) , Adult onset or (ADO)&X-linked Osteopetrosis. ARO is a life threatening condition manifests in first few months with life span of 6 to 10 yrs present with seizures with normal Calcium levels, renal tubular acidosis, cerebral calcification, developmental delay, hypotonia, retinal atrophy & sensorineural deafness. ADO is type I and type II. Type I is associated with reduced number & size of osteoclasts & involvement of ocular nerve while type II is associated with proliferation of large & multinucleated osteoclasts, involvement of facial nerve , bony sclerosis, renal tubular acidosis & cerebral calcification. In X-linked Osteopetrosis severe immunodeficiency is observed with ectodermal changes. The difficulties faced by Anaesthetists are difficult intubation due to facial deformities, head & mandibular involvement cervicomedullery stenosis may lead to cord trauma during intubation difficult spinal & epidural anaesthesia due to scoliosis and short stature. Leucoerythroblastic anaemia, pancytopenia, thrombocytopenia leading to excessive bleeding