In late December 2019, the world woke to a truth of a pandemic of Coronavirus Disease (COVID-19), inspired by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which has a place with a gathering of beta-coronavirus. As of July 21 India is still fighting to survive against the SARS-CoV-2 as called coronavirus disease. The contaminations, first constrained in the Kerala state, have inevitably spread to every single other area. The possibility to cause dangerous respiratory disappointment and quick transmission puts COVID-19 in the rundown of the Public Health Emergency of International Concern (PHEIC). There is a flow overall break out of the novel coronavirus Covid-19, which started from Wuhan in China and has now spread to more than 212 countries including 14,753,034 cases, as of 12:20 AM on July 21, 2020. Governments are feeling the squeeze to prevent the outbreak from spiralling into a worldwide wellbeing crisis. At this stage, readiness, straightforwardness, and sharing of data are vital to hazard evaluations and starting explosion control exercises. Since the episode of serious intense respiratory disorder (SARS) 18 years back, an enormous number of SARS-related coronaviruses (SARSr-CoVs) have been found in their regular repository have, bats. During this epidemic condition, expulsion of biomedical waste created from crisis facilities treating COVID-19 patients in like manner demands unprecedented thought as they can be potential bearers of the disease SARS-CoV-2. This article discusses the potential consequences of the COVID-19 pandemic on biomedical waste administrations, concentrating on basic focuses where option working methodology or extra moderation measures might be fitting.

In India, several (>50) vegetables are widely used as food due to their high nutrition values. However, vegetables in industrial area are getting contaminated with heavy metals by disturbing biological and biochemical processes in the human body. In present study, the risk of human health by heavy metals (Fe, As, Cr, Mn, Cu, Zn, Pb, Cd and Hg) through the intake of common vegetables i.e. Solanum lycopersicum, Solanum melongena, Amaranthus tricolor L., Chenopodium album L., Spinacia oleracea and Coriandrum sativum obtained from the largest coal burning basin, Korba, India is described. The concentration of Fe, As, Cr, Mn, Cu, Zn, Cd, Pb and Hg in the soils (n = 6) was ranged from 18,

Two major issues, i.e. large crop productions and huge anthropogenic activities (e.g. fuel burning and mineral roasting) disturb the micronutrient balance in the soil of India. In this work, the available and total status of eight micronutrients i.e. Fe, Mn, Cu, Zn, Co, Ni, Mo, and S of the soils in the most urbanized area: Raipur area, Chhattisgarh, India (extending over ≈ 2 × 10 4 km 2) is described. The available status of micronutrients i.e. Fe, Mn, Cu, Zn, Co, Ni, Mo and 2 4 SO − in the soils (n = 100) was ranged from 30-8253, 205-2800, 2.0-8.1, 0.7-5.0, 2.2-31.2, 0.1-13.4, 0.1-8.9 and 41-747 mg/kg with mean value of (at 95% probability) 642 ± 186, 1178 ± 119, 4.3 ± 0.3, 2.3 ± 0.2, 12.8 ± 1.3, 3.9 ± 0.6, 1.5 ± 0.3 and 281 ± 25 mg/kg, respectively. The concentration variations, deficiencies and toxicities of the micronutrients in the soil are discussed.

3CL like protease (3CLpro or Mpro) is one of the main proteases of 2019-nCoV. The 3CLpro is a nonstructural protein of SARS-CoV and has an essential role in viral replication and transcription, thus, could be a potential target for anti-SARS drug development. The present study employed ligand-and structure-based approaches to identify the potent inhibitors of 2019-nCoV protease. The e-pharmacophore developed from 3CLpro-1 yielded virtual hits, that were subjected through drug likeliness and PAINS filters to remove interfering compounds. Further comprehensive docking studies, free energy calculations and ADMET studies resulted in two virtual leads-MolPort-000-410-348 and MolPort-002-530-156. The compounds MolPort-000-410-348 and MolPort-002-530-156 displayed good docking score of À12.09 and À13.38 Kcal/mol and free binding energy of À63.34 ± 2.03 and À61.52 ± 2.24 Kcal/ mol, respectively. The compounds also exhibited satisfactory predicted ADMET profile and were subjected to molecular dynamic (MD) studies. The MD simulation produced stable complexes of these ligands with 3CLpro protein and ligand RMSD in acceptable limits.