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Underutilized and less known legumes possess immense nutritional and bioactive attributes based on the traditional knowledge of tribals or local dwellers. The widely distributed genus Canavalia consists of several species serve as the future source of nutraceuticals owing to their capability to grow under extreme conditions. They are well known for proteins, carbohydrates, fiber, essential amino

Concanavalins from Canavalia spp. possess diverse bioactivities and exhibit potent anticancer effects. In this study we assessed the cytotoxic activity of concanavalins from Canavalia spp. on human breast carcinoma MCF-7 cells. The lectins concanavalin A (ConA), concanavalin C (ConC), concanavalin G (ConG) and concanavalin M (ConM) were isolated from seeds of C. ensiformis, C. cathartica, C. gladiata and C. rosea respectively. ConAand ConG demonstrated strong inhibitory effect on MCF-7 cell proliferation with IC values 81.66 µg/mLand 81.09 µg/mLrespectively, with no 50 significant effect in normal kidney HEK293T cells. MCF-7 cells treated with ConA and ConG showed apoptotic morphological changes and accumulation of sub-G /G proportion, suggesting stimulation of apoptotic pathway. These 0 1 results uphold the anticancer potential of concanavalins.