These findings confirm the important trophic and protective role of GH in the homeostasis of the small intestine. The trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I.
Cases:Term male infants were born to consanguineous parents by caesarean section. Maternal antenatal screen was unremarkable. There was no history of gestational diabetes mellitus in the mother. They had healthy sister and brother. The first clinical signs were crying, irritability, cyanosis and poor feeding, observed on the second day of life. Severe persistent hypoglycaemia and hyperinsulinemia during hypoglycaemia (20 mg/dl) were detected in both patients. Their physical examinations were normal.
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