665when injected 15 minutes before or after the virus, less inhibition was observed. The fact that no inhibition of virus growth was demonstrable after 48 hours incubation further suggests that the polypeptides combine with the virus but active virus is subsequently released.The inhibition of tobacco mosaic virus infectivity(2) and this inhibition of the production of influenza virus hemagglutinins by the lysine polypeptides suggest that these or similar synthetic polypeptides might be active against other viruses. The increased activities of the DL-lysine polypeptide and of the DL-lysine-DL-valine polypeptide suggest that the stereochemical structure as well as the amino acid composition of such synthetic polypeptides might be varied in order to produce greater antiviral activity.Preliminary experiments failed to show a significant chemotherapeutic effect against influenza virus in mice when the polypeptides were administered as an aerosol.Summary. Various synthetic high molecular weigh,t lysine polypeptides were found to inhibit the growth of influenza virus in the chick embryo.A severe impairment of antibody response has been observed in pyridoxine(l,2) and pantothenic acid-deficient rats ( 1 ) . Riboflavin, biotin, and thiamine deficiencies had considerably less effect( 1,3,4). In our later experiments ( 5 ) , particular emphasis was placed upon the use of "paired-weighed" in lieu of "paired-fed" rats as controls to the pantothenic acid-deficient animals. The evi-
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