Introduction: Breast cancer is a disease that is increasing its incidence annually, so in search of complementary alternatives for treatment have been studied some medicinal plants containing large amounts of polyphenols, which have anticancer effects as is the case of Cenchrus echinatus L. Objective: To determine the safety and protective effect of ethanol extract of Cenchrus echinatus L. (burdock) on breast cancer induced by 7,12-dimethylbenz[a]anthracene in rats. Methods: Preclinical, experimental study in male Balb/C53 mice and Holtzman rats of both sexes. Acute toxicity and toxicity at 45 days were calculated using probit and OECD methods, respectively; to evaluate the protective effect, the Barros 2004 method was used; tumor cell proliferation was also registered microscopically, using descriptive and inferential statistical analysis, considering p<0.05. Results: Safety studies show that the extract does not induce significant hematologic, biochemical and pathological changes level 80% of the protective effect of the extract against DMBA-induced breast cancer in rats was achieved. Conclusions: It has been shown that Cenchrus echinatus extract L. has protective effect on breast cancer by 7,12-dimethylbenz[a]anthracene induced in rats; and it is not toxic in mice and rats.
Introducción: El Foeniculum vulgare es una planta medicinal de gran importancia por sus propiedades y valor nutricional. Los extractos del hinojo poseen propiedades terapéuticas ante cambios endocrinos, perturbaciones psicológicas, malestares y sintomatología presente en el ciclo vital de la mujer. Objetivos: analizar información sobre las diferentes propiedades y efectos terapéuticos del F. vulgare en las distintas etapas del ciclo vital de la mujer. Metodología: Se realizó una búsqueda crítica y analítica del tema por medio de lenguaje controlado recopilado del MeSH y DeCs en metabuscadores científicos. Resultados: El desarrollo de esta revisión fue viable debido a la variedad de literatura, estudios y ensayos clínicos internacionales de libre acceso de información relevante al tema. Conclusión: Esta planta puede ser empleada como tratamiento, prevención y como fuente de nutrientes; y sus extractos tienen un efecto importante en el ciclo vital de la mujer dependiendo se encuentre en menstruación, menopausia o postmenopausia.
Introduction: Pregnancy is a time of physiological, psychological, personal and social changes for women. The role of the emotional and psychological aspect encompasses the entire period because as fetal development advances, the mother-baby relationship strengthens, making the mother vulnerable. Objectives: To collect, describe and analyze relevant information on mental health in pregnant women, both at different stages of gestation and before and during the COVID-19 pandemic. Methods: A literature search was conducted through PubMed, Google Scholar and Scielo using terminology compiled from MeSH and DeCs. Results: Pregnancy due to hormonal changes causes the presence of anxiety and depression that worsen as the stages of fetal development progress. These psychological disorders have greatly increased during the COVID-19 pandemic due to several reasons such as the relationship with the couple, uncertainty, fear, anguish and increasing phobia about contagion. Final considerations: Pregnant women are a vulnerable population, whose mental health has always been affected and nowadays it has been much more affected due to the pandemic, therefore they need better attention in the health sector such as providing them with reliable information on measures to alleviate the burden of stressors, since they not only carry the anguish of their health but also that of the fetus.
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