In developed countries, endometrial cancer (EC) is one of the most common neoplasms of the female reproductive system. MicroRNAs (miRs) are a class of single-stranded noncoding RNA molecules with lengths of 19–25 nucleotides that bind to target messenger RNA (mRNA) to regulate post-transcriptional gene expression. Although there is a large amount of research focused on identifying miRs with a diagnostic, prognostic, or response to treatment capacity in EC, these studies differ in terms of experimental methodology, types of samples used, selection criteria, and results obtained. Hence, there is a large amount of heterogeneous information that makes it difficult to identify potential miR biomarkers. We aimed to summarize the current knowledge on miRs that have been shown to be the most suitable potential markers for EC. We searched PubMed and Google Scholar without date restrictions or filters. We described 138 miRs with potential diagnostic, prognostic, or treatment response potential in EC. Seven diagnostic panels showed higher sensitivity and specificity for the diagnosis of EC than individual miRs. We further identified miRs up- or downregulated depending on the FIGO stage, precursor lesions, and staging after surgery, which provides insight into which miRs are expressed chronologically depending on the disease stage and/or that are modulated depending on the tumor grade based on histopathological evaluation.
Background: Disseminated peritoneal leiomyomatosis is a rare, benign disease characterized by the proliferation of multiple peritoneal and subperitoneal nodules consisting of smooth muscle cells. Diagnosis is difficult due to its similarity to peritoneal carcinomatosis. less There are 200 cases reported in the world literature. Clinical case: A 29-year-old female with a history of abdominal hysterectomy due to myomatosis 4 years ago, came due to abdominal pain, multiple solid images of different sizes were observed in the tomography, she underwent elective surgery, histological analysis confirmed benign smooth muscle tumors. We present a case operated on in our center.
Antecedentes: Las lesiones quísticas esplénicas son infrecuentes. Se clasifican en tipo 1, con componente epitelial, y en tipo 2 (pseudoquistes), sin componente epitelial. Los pseudoquistes son resultado de traumatismos, infartos o infección. En México no existe ningún caso reportado en el embarazo. Caso clínico: Mujer de 26 años, embarazada, asintomática. Presenta una lesión intraparenquimatosa quística dependiente del bazo, de 25 × 18 × 10 cm. Es sometida a esplenectomía abierta en el segundo trimestre del embarazo, con evolución satisfactoria. El análisis histológico demostró un pseudoquiste esplénico. Describimos el primer caso de pseudoquiste esplénico en una paciente embarazada en México.
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