Innovation and technology, which are part of the debate in the knowledge society, are linked to the creation of a prosperous environment that benefits them, the result of multiple and coordinated action of three factors: government, productive structure and technological and scientific infrastructure. The investigation starts from the following question: What is the best methodology for managing the structures known as Science and Technology Parks? The objective of the research is to develop a management model for the Scientific and Technological Park of the Missions Region in order to optimize its economic and financial self-sufficiency so that it does not depend exclusively on resources from the University or from public notices. In methodological terms, the research is a qualitative one, of an applied nature since its results will be used in practice to solve a specific problem. As preliminary results, a self-sustainable management model for the Scientific and Technological Park of the Missions is presented, considering its specificities and peculiarities. This model was developed from the investigation of the main methodologies used in PCTs in different regions of the world and in Brazil, with the purpose of indicating the most appropriate strategies for the implantation of PCTs in a farming region, as well as, identifying the regional base actors technology to understand the operation of the Triple Helix.
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