The pyrrolidine nucleus has been incorporated into many anticholinergic drugs as the basic moiety of the dialkylaminoalkyl substituted-phenylacetate type. These compounds can be divided into two main structural categories-those in which pyrrolidine serves as the terminal basic group of the alkyl chain (I); and those in which the nucleus itself is part of the aminoalkyl chain (II).1-4
Fenfluramine hydrochloride (N‐ethyl‐α‐methyl‐3‐trifluoromethylphenethylamine hydrochloride; AHR‐965) administered orally or intravenously to anaesthetised or unanaesthetised dogs, caused a predominant rise in arterial blood pressure, tachycardia, an increase in myocardial contractile force and cardiac output, and an enhanced total peripheral resistance. Fenfluramine was qualitatively like dexamphetamine in its cardiovascular effects; however dexamphetamine was 10 to 20 times more potent as a pressor agent.
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