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Provided that DMF (or another N,N-dialkylformamide) is present in the reaction medium, at least in a catalytic amount, fluoroform trifluoromethylates efficiently carbonyl compounds, even enolizable ones, when opposed to (TMS)(2)N(-) M(+), generated in situ from N(TMS)(3) and M(+) F(-) or RO(-) Na(+). When F(-) is used in a catalytic amount, silylated alpha-(trifluoromethyl)carbinols are obtained: in this case, the four-component system HCF(3)/N(TMS)(3)/catalytic F(-)/catalytic DMF behaves like the Ruppert's reagent, especially as far as nonenolizable carbonyl compounds are concerned (CF(3)SiMe(3) remains more efficient for enolizable carbonyl compounds). This process involves an adduct between DMF and (-)CF(3) which is the true trifluoromethylating agent. In the same way, fluoroform efficiently trifluoromethylates disulfides and diselenides when deprotonated with a strong base selected from t-BuOK or N(SiMe(3))(3)/Me(4)NF (or TBAT). t-BuOK is more adapted to the trifluoromethylation of aryl disulfides whereas N(SiMe(3))(3)/F(-) is well suited to that of aliphatic disulfides.

The reaction of tetrabutylammonium triphenyldifluorosilicate with 2,4-dinitro(trifluorometh-

The electrochemical oxidation of potassium trifluoromethanesulfinate (CF 3 SO 2 K) in the presence of electron-rich aromatics and alkenes provides the corresponding trifluoromethylated products.

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Fluorinated moieties constitute important substituents used in many applications to modify the properties of molecules. The action of DAST onto Ruppert's reagent yields to a not isolable intermediate that can then react with various primary amines to give trifluoromethanesulfinamidines and trifluoromethanesulfanylamides. Such compounds were unknown until now and constitute interesting new families of fluorinated molecules.

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