Background The number of treatment options in psoriasis has increased considerably, so biomarkers should be searched to assist in the selection of the optimal treatment agent. The most common of these biomarkers is HLA-Cw6. Objective: The aim was to determine whether there is a relationship between HLA-Cw6-positivity (HLA-Cw6-POS) and the response of treatment agents in psoriasis. Methods: Blood samples of 124 patients were subjected to genetic study for HLA-Cw6. Results: Psoriasis area severity index (PASI) score of more than 75% (PASI75) response was received in 34 (73.9%) of the HLA-Cw6-POS methotrexate-treated patients, 30 (78.9%) of the HLA-Cw6-POS cyclosporine-treated patients, and 8 (37.5%) of the HLA-Cw6-POS acitretin-treated patients. The differences were not statistically significant (P = 0.634-0.071-0.409). PASI75 response was received in 73 (68.2%) of the HLA-Cw6-POS patients in patients treated with conventional agents. In adalimumab-treated patients, PASI75 response was received in 8 (53.3%) of the HLA-Cw6-POS patients, 6 (75%) of the HLA-Cw6-POS infliximab-treated patients, and 4 (57.1%) of the HLA-Cw6-POS ustekinumab-treated patients. The differences were not statistically significant (P = 0.245-1.00-0.322). PASI75 response was received in 24 (64.9%) of the HLA-Cw6-POS and 33 (84.6%) of HLA-Cw6 negative (HLA-Cw6-NEG) patients with biological agents. The biological agent response was statistically significantly lower in HLA-Cw6-POS. Conclusion: None of the agents were affected by HLA-Cw6. When biological agents were evaluated collectively, the treatment response of HLA-Cw6-POS patients was lower.
Aim Several studies were conducted to determine the characteristics of hospitalized patients with Herpes Zoster. This study aimed to evaluate the characteristics of hospitalized especially elderly patients with Herpes Zoster and compare them with young adult patients in tertiary clinic in Turkey. Material and Methods Hospitalized HZ patients were enrolled 2008 and 2020. Age, gender, length of hospitalization, affected dermatomes, treatment agents, comorbidities, complications were recorded from the electronic medical files. Results Totally 82 patients were evaluated. 62.2% (n=51) of the patients were over 65 years old. In the group over 65 years of age, the proportion of female patients were 54.9% (n=28), cervical dermatome involvement was 49% (n=25), the most common comorbidity is hypertension, the proportion of comorbid patients was 92.2% (n=47), the proportion of immunosuppressive patients were 39.2% (n=20), the most common complication was acute neuralgia, the proportion of complicated patients was 68.6% (n=35), the most commonly used treatment agents were valacyclovir and NSAID. The mean length of hospital stay was 11.9 days. Conclusion Elderly hospitalized patients with HZ tend to be more complicated and have longer hospital stays. Therefore, early treatment is important in this group.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.