Objectives: The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses. Material and methods:Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, Ankara, Turkey, between November 2010 and March 2011. Fifty patients with a suspicion of malignant adnexal mass and 30 controls were included in the study. Serum and urine CA-125, HE4, and bcl2 levels were evaluated for their role in the diagnosis of epithelial ovarian cancer (EOC).Results: Serum CA-125 and HE4 levels, and urine HE4 levels were significantly higher in malignant cases as compared to controls (p < 0.05). Mean levels of bcl2 in saliva and urine were similar in malignant cases and controls (p > 0.05). Conclusions:We demonstrated that serum CA125, serum HE4 and urine HE4 levels were elevated in patients with ovarian cancer. These findings should be assessed in future studies with larger sample sizes in order to reach more definite conclusions.

Background: Adnexal mass in pregnancy is a rare situation in daily clinical practice. Also, there is no consensus about the management of the adnexal mass diagnosed during pregnancy. Material methods: In this study,we retrospectively identified adnexal mass which was diagnosed during antenatal follow-up or cesarean section between 2000-2009 in Baflkent University Hospital,Department of obstetricsgynecology.Labor-delivery unit database, hospital records and pathology reports were evaluated in order to retrive the age of patients, number of gravida and parity, initial symptoms, the gestational age and the diameter of cyst, antenatal complications, time of delivery birth weight, indication of cesarean delivery, the type of surgical intervention during cearean delivery and pathology of the cyst. Results: We identified 27 pregnancy complicated with adnexal masses among the 2150 delivery (1.25%). Among these,25 of 27 pregnants were asymptomatic (92,6%) while just 2 pregnant women came with the complaint of pain. In 2 of the patients (7,4%) the cyst was known before the pregnancy while in 6 pregnant women (22,4%) the cyst was diagnosed during antenatal care. Also, rest of the women (n=19, 70,4%) were diagnosed during cesarean. The 3 of the cysts (11,1%) was smaller than 6 cm while another 3 of the cysts (11,1%) was greater than 6 cm. Cesarean and cystectomy was performed in 23 of this women. On the other hand, 2 of them had cesarean and unilateral

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