No abstract

No abstract

No abstract

Ketanserin, a selective 5-HT2 serotonergic receptor antagonist, reduces in vitro the release-associated human platelet aggregation induced by threshold concentrations of collagen and curtails the second wave of aggregation/release induced by critical concentrations of ADP in particular and, to a lesser extent, of 1-epinephrine. Its inhibitory effect on the second waves becomes more pronounced when the reaction is already attenuated by moderate cyclo-oxygenase inhibition with esculetin, by yohimbine or by propranolol. The first wave of aggregation induced by ADP or 1-epinephrine is not affected. Such an inhibition of secondary platelet recruitment by ketanserin in vitro may be due to an inhibition of the 5-HT2 receptor-mediated amplifying effects of platelet-released 5-HT or to a non-specific interference with the platelet membrane, reducing the release of mediators from the platelets. Reduction of the increased plasma BTG levels in patients after ketanserin may result from such release-inhibiting mechanisms.

Summary. Guinea pigs, infected with either Trichophyton mentagrophytes or Microsporum canis, were treated orally or topically with azole antifungals daily for two weeks. Fungi located in the stratum corneum were affected similarly by both treatment schedules, showing typical cell wall changes after azole exposure and necrosis of internal organelles. Fungi located in the hair sheaths were affected only by the oral treatment, which not only prevented invasion of the inner hair structures and inflammatory responses but also led to a complete clearance of the infection within 7 days. Topically applied azole treatment was not able to injure fungi in the hair sheaths and did not suppress invasion into the hair shafts. These observations are in favour of oral antifungal medication with azoles for the treatment of der‐matophyte infections involving hairy skin. Zusammenfassung. Mit Trichophyton mentagrophytes oder Microsporum canis infizierte Meer‐schweinchen wurden zwei Wochen lang täglich oral bzw. lokal mit antimykotischen Azolen behandelt. Beide Behandlungsweisen zeigten ähnliche Auswirkungen auf im Stratum corneum angesiedelte Pilze nach Azol‐Exposition, nämlich typische Zellwandveränderungen und Nekrose interner Organellen. Bei in den Haarscheiden angesiedelten Pilzen zeigte nur die orale Behandlung Wirkung. Es wurden nicht nur eine Invasion der inneren Haarstruktur und entzündliche Reaktionen vermieden, sondern die Infektion wurde innerhalb von 7 Tagen vollständig zum Abklingen gebracht. Die lokale Azolbehandlung konnte die Pilze in den Haarscheiden nicht schädigen und verhinderte nicht das Eindringen in die Haarschäfte. Diese Beobachtungen sprechen für eine orale antimykotische Medikation mit Azolen zur Behandlung von Dermatophyten‐Infektionen behaarter Hautpartien.