This study focused on Oeosophagostomum sp., and more especially on O. bifurcum, as a parasite that can be lethal to humans and is widespread among humans and monkeys in endemic regions, but has not yet been documented in apes. Its epidemiology and the role played by non-human primates in its transmission are still poorly understood. O. stephanostomum was the only species diagnosed so far in chimpanzees. Until recently, O. bifurcum was assumed to have a high zoonotic potential, but recent findings tend to demonstrate that O. bifurcum of non-human primates and humans might be genetically distinct. As the closest relative to human beings, and a species living in spatial proximity to humans in the field site studied, Pan troglodytes is thus an interesting host to investigate. Recently, a role for chimpanzees in the emergence of HIV and malaria in humans has been documented. In the framework of our long-term health monitoring of wild chimpanzees from Kibale National Park in Western Uganda, we analysed 311 samples of faeces. Coproscopy revealed that high-ranking males are more infected than other individuals. These chimpanzees are also the more frequent crop-raiders. Results from PCR assays conducted on larvae and dried faeces also revealed that O. stephanostomum as well as O. bifurcum are infecting chimpanzees, both species co-existing in the same individuals. Because contacts between humans and great apes are increasing with ecotourism and forest fragmentation in areas of high population density, this paper emphasizes that the presence of potential zoonotic parasites should be viewed as a major concern for public health. Investigations of the parasite status of people living around the park or working inside as well as sympatric non-human primates should be planned, and further research might reveal this as a promising aspect of efforts to reinforce measures against crop-raiding.

To identify the epidemiological and genetic characteristics of norovirus (NoV) outbreaks and estimate the impact of NoV infections in an older population, we analysed epidemiological and laboratory data collected using standardized methods from long-term care facilities (LTCFs) during 2003-2006. Faecal specimens were tested for NoV by real-time reverse transcriptase-polymerase chain reaction. NoV strains were genotyped by sequencing. Of the 234 acute gastroenteritis (AGE) outbreaks reported, 163 (70%) were caused by NoV. The annual attack rate of outbreak-associated NoV infection in LTCF residents was 4%, with a case-hospitalization rate of 3·1% and a case-fatality rate of 0·5%. GII.4 strains accounted for 84% of NoV outbreaks. Median duration of illness was longer for GII.4 infections than non-GII.4 infections (33 vs. 24 h, P<0·001). Emerging GII.4 strains (Hunter/2004, Minerva/2006b, Terneuzen/2006a) gradually replaced the previously dominant strain (Farmington Hills/2002) during 2004-2006. NoV GII.4 strains are now associated with the majority of AGE outbreaks in LTCFs and prolonged illness in Oregon.

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Background: South Africa has among the highest rates of intimate partner violence (IPV) globally, with young women at heightened risk due to inequitable gender roles, limited relationship skills, and inadequate social support. Despite an urgent need for low-cost, scaleable IPV solutions, most efficacious approaches are time-intensive and costly to deliver. Digital, interactive chatbots could deliver behaviourally-informed strategies to help young women navigate their relationships in the context of high IPV prevalence. Methods: Young women (18-24 years old) across South Africa were recruited via Facebook for participation in an individually randomised controlled trial (n=19,643). Users were randomly allocated, using a pipeline algorithm, to one of four trial arms: Pure Control (PC) had no user engagement outside of study measures; Attention Treatment (T0) provided didactic information about sexual health through a text-based chatbot; Gamified Treatment (T1) was a behaviourally-informed gamified text-based chatbot; Narrative Treatment (T2) was a behaviourally-informed drama delivered through pre-recorded voice notes. All chatbots were delivered in WhatsApp, through which users were invited to complete brief “quizzes” comprising adapted versions of validated scales. A direct chat link to a trained counsellor was a safety measure (and was accessed by 4·5% of the sample). Primary outcomes were adapted validated scales of gender beliefs and past-month IPV. Secondary outcomes were identification of unhealthy relationship behaviours and depressive symptoms. We estimated treatment effects using ordinary least squares and heteroskedasticity robust standard errors.Findings: Compared to control, all treatments were effective in improving gender beliefs (Cohen’s D=0·10, 0·29, 0·20 for T0, T1, and T2, respectively). The gamified chatbot (T1) had small but significant effects on IPV: 56% of young women reported past-month IPV, compared to 62% among those without treatment (marginal effects=-0·07, 95%CI=-0·09to-0·05). The narrative treatment (T2) had no effect on IPV exposure. T1 significantly increased identification of unhealthy relationship behaviours (Cohen’s D=0·25). Neither T1 nor T2 had a measurable effect on mental health, nor did either treatment arm cause mental distress.Interpretation: A behaviourally-informed, gamified chatbot increased gender equitable beliefs and skills and was protective for IPV exposure among young women in South Africa. These effects, while modest in magnitude, could represent a meaningful impact were the gamified chatbot to be scaled.