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Conditions in a black hole outburst The binary system V404 Cygni consists of a red giant star orbiting a black hole. In 2015, a surge of accretion by the black hole caused the surrounding plasma to brighten suddenly for the first time since 1989, briefly becoming the brightest x-ray source in the sky. Dallilar et al. combined observations from radio, infrared, optical, and x-ray telescopes taken during the outburst. They compared how fast the flux decayed at each wavelength, which allowed them to constrain the size of the emitting region, determine that the plasma within it cooled through synchrotron radiation, and measure the magnetic field around the black hole. Science , this issue p. 1299

We have established an optimal condition for the synchronous digestion of SV40 DNA with Escherichia coli exonuclease III. Electron microscopy and polyacrylamide gel electrophoresis were used to obtain accurate measurements on the lengths of DNA before and after exonuclease III digestion. Based on this finding, a new method for determining the sequence of long duplex DNA can be realized. It involves (a) the synchronous digestion of the DNA from the 3' ends with exonuclease III, followed by (b) repair synthesis with labeled nucleotides and DNA polymerase, and (c) sequence analysis of the repaired DNA.

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