Cullin RING E3 ligases require covalent modification with Nedd8 for activity. Neddylation is reversed by the COP9 signalosome (CSN). We characterize the role of CSN-dependent deneddylation in vivo and propose a model in which CSN binds to cullin ligases in their active conformation and functions to recruit important regulatory factors.

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This debates essay offers a summary and critique of the chapter “Cheap Energy” in A History of the World in Seven Cheap Things by Jason W Moore and Raj Patel. In the text of my comment, I suggest that this work—while intellectually generative—pays insufficient attention to broader analytical and theoretical debates within Global Political Economy and the study of science and technology that its analysis addresses. Additionally, the authors do not address the failure of the only major attempt to jettison the price mechanism as a system for allocating resources under conditions of industrialization—the Marxist-Leninist command economies—to generate anything approaching a sustainable society.