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Phytochemical screening and evaluation of antidiabetic activity of leaf extracts of Viscum album from four different plant hosts were carried out using standard procedures. The results of the phytochemical screening revealed that the different leaf extracts vary in their phytochemical constituents depending on the plant host. Moreso, all the leaf extracts of Viscum album demonstrated significant (p<0.001) lowering of blood glucose level (BGL) in alloxan-induced diabetic rats. The leaf extract of V. album from Dennettia tripetala exhibited the highest antidiabetic activity than the other extracts followed by Citrus sinensis and Pisium guajava and their activities were more pronounced than that of standard drug, glibenclamide during acute study. On prolonged treatment, Viscum album leaf extracts from C. sinensis (VAC ) and P. guajava (VAP) had comparably higher antidiabetic effects than the other extracts and glibenclamide. These were followed by that from Dacroydes edulis (VAD) while Dennettia tripetala (VADT) had the lowest antidiabetic effect. Although V. album possesses antidiabetic property, its antidiabetic efficacy depends on its phytochemical constituents which in turn depends on the plant host.

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