Flufenamic acid is more potent than phenylbutazone as an anti-inflammatory agent in guinea pigs (ultraviolet erythema) and rats (granulation on subcutaneous cotton pellets), without evidence of adrenal dependence or cortieoid hormonal effects. Its antipyretic potency in rats approximates that of phenylbutazone. Like phenylbutazone and unlike aminopyrine, it had no antinocicep tive effect in rat tail-pinching experiments. In ordinary concentrations as the sodium salt, it is a tissue irritant in rodents. Supratherapeutic oral doses were well tolerated.Acido flufenamic es plus potente gue phenylbutazona como agente anti-inflammatori in porcos de India (erythema ultraviolette) e rattos (granulation super subcutanee pellets de coton), sin evidentia de dependentia adrenal o de affectos corticoido-hormonal. Su potentia antipyretic in rattos es approximativemente ill0 de phenylbutazona. Como phenylbutazona e per contrast0 con aminopyrina, ill0 habeva nulle eff ecto antinociceptive in experimentos de pinceage de cauda in rattos. In concentrationes ordinari e usate como sal de natrium, ill0 es un irritante de tissu in rodentes. Supratherapeutic doses oral esseva ben tolerate. E HAVE REPORTED that N-( 2,3-~ylyl)anthranilic acid (mefenamic acid) antagonizes the erythema in guinea pigs' skin foIlowing ultra-violet irradiation, and that it partially depresses inflammatory granulation tissue growth, is antipyretic, and is antin0ciceptive.l Such new antipreinflammatory2 compounds provide tests, beyond those provided by agents already known to therapy, of a working hypothesis that the anti-UV-erythema efficacy is closely correlated with and highly predictive of a nonsteroidal kind of antirheumatic efficacy? The compound to be described here, N-( ar,ar,a-trifluoro-m-tolyl ) -anthranilic acid4 (CI-440; flufenamic acid),* was found to be more potent than mefenamic acid or phenylbutazone in antagonizing the UV-erythema. Like phenylbutazone and mefenamic acid, it also partially depresses inflammatory granulation tissue growth and is antipyretic. However, like phenylb~tazone,~ it differs from mefenamic acid in failing to exhibit antinociceptive action in rat tail-pinching experiments. MATERIALS AND METHODSCI-440 i5 a cream-colored, solid carboxylic acid of molecular weight 281.2:From the
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.