A challenging step in the preparation of tetrahydrocannabinol analogs is an acid-catalyzed intramolecular cyclization of the cannabidiol precursor. This step typically affords a mixture of products, which requires extensive purification to obtain any pure products. We report the development of two continuousflow protocols for the preparation of (−)-trans-Δ 9 -tetrahydrocannabinol and (−)-trans-Δ 8 -tetrahydrocannabinol.
The hydroalkylation of nitroalkenes and β-nitroacrylates via a photocatalytic strategy has been optimised under both batch and continuous flow conditions. This target has been achieved by exploiting the potentialities of the decatungstate anion as a versatile hydrogen atom transfer (HAT) photocatalyst for the generation of alkyl radicals from aliphatic heterocycles, amides and cycloalkanes.
Herein we report a new practical and efficient preparation of the flavonoid Luteoloside. The title target has been obtained with an excellent overall yield of ~40% via a four multistep synthetic approach.
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