An unprecedented direct C-H bond functionalization of unprotected phenols with α-aryl α-diazoacetates and diazooxindoles was developed. A tris(2,4-di-tert-butylphenyl) phosphite derived gold complex promoted the highly chemoselective and site-selective C-H bond functionalization of phenols and N-acylanilines with gold-carbene generated from the decomposition of diazo compounds, furnishing the corresponding products in moderate to excellent yields at rt. The salient features of this reaction include readily available starting materials, unprecedented C-H functionalization rather than X-H insertion, good substrate scope, mild conditions, high efficiency, and ease in further transformation. To the best of our knowledge, this is the first example of C-H functionalization of unprotected phenols with diazo compounds.

Isotropic 3D fast spin-echo imaging versus standard 2D imaging at 3.0 T of the knee-image quality and diagnostic performance Abstract The objective of this study was to compare a newly developed fat-saturated intermediate-weighted (IM-w) 3D fast spin-echo (FSE) sequence with standard 2D IM-w FSE sequences regarding image quality and diagnostic performance in assessing abnormal findings of the knee. MR imaging was performed at 3.0 T in 50 patients. Images were assessed independently by three radiologists. Image quality was rated significantly higher (p<0.05) for the 2D versus the 3D FSE sequences. Sensitivity for cartilage lesions was slightly higher for the 3D sequence, but specificity was lower. Low contrast objects were better visualized with 2D sequences, while high contrast objects were better shown with the 3D sequence. Confidence scores were higher for 2D than for 3D sequences, but differences were not significant. In conclusion, isotropic 3D FSE IM-w imaging may enhance standard knee MRI by increased visualization of high contrast lesions; however, 3D FSE image quality was lower.

The development of an efficient method for the site‐selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo‐ and ortho‐selective substitution reaction of phenols with α‐aryl α‐diazoacetates with commercially available (C6F5)3B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.

The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with α-aryl α-diazoacetates with commercially available (C F ) B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.

The use of 3D-printed cutting guides and locking guides can increase the precision of the MCWDFO in patients with lateral compartment disease and valgus deformity, making our surgery more efficiency and occupying less fluoroscopic time.

Herein, we report a gold-catalyzed highly site-selective C(sp)-H functionalization of unactivated arenes with α-aryl-α-diazoesters with electron-withdrawing substituents as induced groups on aryl rings. Furthermore, the induced groups are useful for further synthetic transformations.

The polymer-bound Ming-Phos was easily prepared by the highly efficient immobilization of our recently developed Ming-Phos in polystyrene by copolymerization in the presence of 5% DVB, which shows good performance in the application of heterogeneously catalyzed asymmetric cycloaddition. A pair of enantiomers of the product with opposite configurations could be easily delivered in high yields with excellent enantioselectivity by the application of two diastereomers of the heterogeneous catalyst. This heterogeneous catalyst not only exhibits similar catalytic activity and enantioselectivity to those of the homogeneous catalyst but also could be easily recovered and recycled for up to eight cycles.

Compared to the most popular directing-group-assisted strategy, the "undirected" strategy for C-H bond functionalization represents a more flexible but more challenging approach. Reported herein is a gold-catalyzed highly site-selective C(sp )-H alkylation of unactivated arenes with 2,2,2-trifluoroethyl α-aryl-α-diazoesters. This protocol demonstrates that high site-selective C-H bond functionalization can be achieved without the assistance of a directing group. In this transformation, both the gold catalyst and trifluoroethyl group on the ester of the diazo compound play vital roles for achieving the chemo- and regioselectivity.