A simple modification of the standard rotarod apparatus is described which eliminates the necessity of time‐consuming training and consequently gives a truer measure of motor co‐ordination since any effects on memory are avoided. The sensitivity and reproducibility of the procedure are much greater than those obtained with constant speed rotarods and less animals are required to obtain statistically significant results.

No abstract

A new method to tag the barium daughter in the double-beta decay of ^{136}Xe is reported. Using the technique of single molecule fluorescent imaging (SMFI), individual barium dication (Ba^{++}) resolution at a transparent scanning surface is demonstrated. A single-step photobleach confirms the single ion interpretation. Individual ions are localized with superresolution (∼2  nm), and detected with a statistical significance of 12.9σ over backgrounds. This lays the foundation for a new and potentially background-free neutrinoless double-beta decay technology, based on SMFI coupled to high pressure xenon gas time projection chambers.

No abstract

The IceCube Neutrino Observatory at the South Pole has measured the diffuse astrophysical neutrino flux up to ∼PeV energies and is starting to identify first point source candidates. The next generation facility, IceCube-Gen2, aims at extending the accessible energy range to EeV in order to measure the continuation of the astrophysical spectrum, to identify neutrino sources, and to search for a cosmogenic neutrino flux. As part of IceCube-Gen2, a radio array is foreseen that is sensitive to detect Askaryan emission of neutrinos beyond ∼30 PeV. Surface and deep antenna stations have different benefits in terms of effective area, resolution, and the capability to reject backgrounds from cosmic-ray air showers and may be combined to reach the best sensitivity. The optimal detector configuration is still to be identified. This contribution presents the full-array simulation efforts for a combination of deep and surface antennas, and compares different design options with respect to their sensitivity to fulfill the science goals of IceCube-Gen2.