Objective

A 72-year-old man presented to the hospital with exacerbation of congestive heart failure. He was given furosemide 40 mg intravenously twice at 4 hours apart. At 4 hours after the second dose of furosemide, his white blood cells (WBC) dropped acutely from 9.8 to 2.4×10/L (reference range 4.1 to 9.3×10/L). With the discontinuation of furosemide, the WBC trended up to 7.1×10/L about 13 hours after the second dose of intravenous furosemide and remained in normal range for the next 3 days. However, when the oral furosemide was started on hospital day 4, there was a mild drop in WBC count, which returned to and maintained at baseline since the next day. The dynamic changes in the patient's WBC were coincident with the use of furosemide. The possible mechanisms of furosemide-associated transient hyperacute leucopenia were discussed.

CASEA 35-year-old white woman was admitted to the hospital after an episode of diabetic ketoacidosis (DKA) that was treated per protocol. Physical examination revealed mild hirsutism and the presence of large plaques about 10 cm by 2 to 4 cm (3.9 by 0.8 to 1.6 inches) in size with irregular brownish borders and telangiectatic, somewhat atrophic centers on the bilateral pretibial surfaces (Figure 1). The lesions were not tender upon palpation. The patient said that the lesions developed several years before she was diagnosed with diabetes and have progressively enlarged.

No abstract