In critically ill patients presenting to the emergency department with early septic shock, EGDT did not reduce all-cause mortality at 90 days. (Funded by the National Health and Medical Research Council of Australia and the Alfred Foundation; ARISE ClinicalTrials.gov number, NCT00975793.).

Early sedation depth independently predicts delayed extubation and increased mortality, making it a potential target for interventional studies.

No abstract

The 2009 H1N1 virus had a substantial effect on ICUs during the winter in Australia and New Zealand. Our data can assist planning for the treatment of patients during the winter in the Northern Hemisphere.

EGDT is not superior to usual care for ED patients with septic shock but is associated with increased utilisation of ICU resources.