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The potential of veterinary antibiotics (VAs) to impact human and environmental health requires the development and evaluation of land management practices that mitigate VA loss from manuretreated agroecosystems. Vegetative buffer strips (VBS) are postulated to be one management tool that can reduce VA transport to surface water resources. The objectives of this study were to (1) investigate oxytetracycline (OTC) and sulfadimethoxine (SDT) sorption to agroforestry buffer, grass buffer, and cropland soils, (2) evaluate differences in VA sorption to soils collected from different vegetative management and soil series, and (3) elucidate relationships between soil properties and VA sorption. Sorption/extraction isotherms for OTC were well-fitted by the Freundlich isotherm model (r 2 [ 0.86). OTC was strongly adsorbed by all soils and the VA was not readily extractable. OTC and SDT solid to solution partition coefficients (K d ) values are significantly greater for soils planted to VBS relative to grain crops. Significant differences in OTC and SDT K d values were also noted among the soil series studied. Linear regression analyses indicate that clay content and pH were the most important soil properties controlling OTC and SDT adsorption, respectively. Results from this study suggest that agroforestry and grass buffer strips may effectively mitigate antibiotic loss from agroecosystems, in part, due to enhanced antibiotic sorption properties.