Bioreducible FA-PEG-b-P(α-Pt(ii)-SS-CL/CL) conjugates have been successfully developed in order to build redox-responsive micelles with targeting and site-specific drug releasing abilities.
Herein, novel magnetic nanoparticles with pyridinium bridges namely Fe3O4@SiO2@PCLH-TFA through a multi-step pathway were designed and synthesized. The desired catalyst and its corresponding precursors were characterized with different techniques such as Fourier transform infrared (FT-IR) spectroscopy, 1H NMR, 13C NMR, Mass spectroscopy, energy dispersive X-ray (EDX) analysis, thermogravimetric/derivative thermogravimetry (TG/DTG) analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). In addition, the catalytic application of the prepared catalyst in the synthesis of new series of triarylpyridines bearing sulfonate and sulfonamide moieties via a cooperative vinylogous anomeric-based oxidation was highlighted. The current trend revealed that the mentioned catalyst shows high recoverability in the reported synthesis.
In this study, a new and stable Ce(IV) immobilized on halloysite nanotubefunctionalized dendrimer was designed, synthesized, and characterized using Fourier-transform infrared, elemental analysis, thermogravimetric analysis, field emission scanning electron microscopy, scanning electron microscopyenergy dispersive X-ray spectroscopy, transmission electron microscopy, dynamic light scattering, Brunauer-Emmett-Teller, and inductively coupled plasma optical emission spectroscopy techniques. This catalyst was efficiently used for the one-pot, single-step multicomponent synthesis of pyrido[3,2-c] coumarins from 4-aminocoumarin, aldehydes, and aryl ketones. The efficiency and selectivity of this catalytic system were also evaluated for the synthesis of pyrido[3,2-c]coumarins from terminal/internal alkynes instead of aryl ketones. In this respect, the regioselectivity of the products was successfully assigned by X-ray crystallographic analysis. All these reactions were best performed under solvent-free conditions in the presence of only 0.28 mol% of the catalyst, and such a one-pot multicomponent synthesis of pyrido[3,2-c]coumarins is reported for the first time. It is also worth noting that single-step and short reaction path for the synthesis of a variety of pyrido[3,2-c]coumarins along with excellent reusability of this dendritic catalyst makes this method economically and environmentally attractive.
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