Aim: These ethnobotanical investigations within drug sellers of medicinal plants in Côte d'Ivoire (CI) were performed in order to contribute to a better knowledge of plants with antidiabetic effect. They were carried in Adjamé "Quartier rouge" in the district of Abidjan. Methods and Results: The results obtained allowed to inventory 16 species of medicinal plants belonging to 13 families. All of these species are used in the treatment of various pathologies such as diabetes. In order to establish the safety of these plants in the diabetic treatment, acute toxicity tests were performed. To this end, the LD50 was determined in rats. It was determined haematological and biochemical parameters after repeated dosing of 2000 mg/kg of body weight (bw) of aqueous extract of Calotropis procera„leaf, Bauhinia thonningi‟fruit, Fagara zanthoxyloides‟barks and Cassia siberiana‟roots to those rats during 14 days. The aqueous extracts had no effect on most of blood parameters tests. These studies have shown that aqueous extracts of these plants were not toxic in the experimental dose. Conclusion: This study was conducted in the context to perform pharmacological and toxicological experiments for implementation of innovative initiatives in Côte d‟Ivoire. That may lead in the future, to the manufacture of improved traditional drugs (TID).
Background Diabetes is up to four times more common in HIV-infected individuals exposed to antiretroviral therapy. Haematological parameters are important indicators for the assessment and management of patients with diabetes. The aim of this study was to determine the correlations between biochemical and haematological parameters in type 2 diabetic patients living with HIV. Methods A total of 260 participants consisting of 100 HIV-positive and 160 HIV-negative diabetics. Blood samples were obtained from fasting subjects by venipuncture at the elbow. They were used to obtain plasma and serum after centrifugation at 3000 rpm for 15 minutes. Creatinine, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, C-reactive protein, magnesium, phosphorus, urea, uric acid and cystatin C, glycated haemoglobin, blood glucose and blood count were measured. Results The correlation between the biochemical and haematological profile showed that blood glucose correlated positively with white blood cell count (r=0.204, p=0.042), red blood cell count (r=0.216, p=0.031), neutrophil count (r=0.265, p=0.008), basophil count (r=0.229, p=0.022), monocyte count (r=0.271, p=0.006) and lymphocyte count (r=0.205, p=0.041). This correlation was negative for mean blood volume (r=-0.202, p=0.043). Phosphorus was negatively correlated with mean corpuscular haemoglobin concentration (r=-0.245, p=0.014) and monocyte count (r=-0.24, p=0.016), but positively correlated with eosinophil count (r=0.256, p=0.010). Conclusion Disturbances in the biochemical and haematological profiles were observed in diabetics living with HIV. The correlations found in these two associated chronic pathologies showed the link of blood glucose with many of haematological parameters.
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