Introduction: Multiple sclerosis (MS) is a demyelinating and autoimmune disease that affects the central nervous system (CNS). It is the most common CNS disabling disease in young adults, predominantly in the 20-40 age group. Patients with MS have a compromised quality of life. The Short Form Health Survey 36 (SF-36) is the most widely used questionnaire to assess quality of life in patients with MS. Objectives: To analyze the quality of life of patients diagnosed with relapsingremitting multiple sclerosis (RRMS), in a Reference Center for Multiple Sclerosis in Paraíba. Methods: This is a cross-sectional field work of quantitative approach, of descriptive and exploratory nature. The SF-36 questionnaire was applied in April 2021, at the Reference Center for Multiple Sclerosis. At the study site, 390 patients with Multiple Sclerosis were registered. For the research to present a confidence level of 90% and an expected error of 10%, a sample of 58 patients was determined. The statistical data were made by IBM SPSS statistics. The study was approved by the Research Ethics Committee of Joao Pessoa University Center. Results: The data found in the sample are compatible with what is described in literature, reaffirming the predominance of MS for the female gender of 77%. As for the analysis of the patients’ quality of life, the domains with the most impairment were limitation by emotional aspects, followed by vitality and limitation by physical aspects. The use of Betainterferone 1a was associated with a better quality of life in six of the eight domains studied. Conclusion: Patients with RRMS have a decreased perception of Quality of Life. Other factors that affect the quality of life of these patients are gender and the use of betainterferone 1a.
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