Introduction: In the scenario of dental enamel hypoplasia, Molar Incisor hypomineralization (MIH) represents qualitative enamel developmental defects. The prevalence of MIH is approximately 13% worldwide. In addition, children affected by MIH undergo dental treatment on their first permanent molars nearly ten times as often as children without MIH. Objective: It was to carry out a systematic review of clinical studies on the use of ICON® in dental enamel hypoplasia, to discuss the advantages of this resin in patients. Methods: The present study followed a systematic review model, following the rules of systematic review – PRISMA. The search strategy was performed in the PubMed, Cochrane Library, Web of Science and Scopus, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 122 articles were found. A total of 46 articles were fully evaluated and 25 were included in this study. Based on recent findings in the literature, the aesthetic results of ICON® infiltration proved to be effective, both in visual qualitative and quantitative spectrophotometric assessment. Furthermore, the infiltration of ICON® positively influenced the maintenance of the structural integrity of teeth affected by MIH, reducing the risk of enamel breakage. It also proved to be a minimally invasive treatment for tooth discoloration, less aggressive than conventional procedures. In addition to masking enamel white spot lesions, resin infiltration can involve residual enamel crystallites forming a hybrid enamel layer. Regarding the highest penetration and the highest percentages of penetration area, ICON® proved to be better than other resins such as Biscover LV (Bisco), Optiguard (Kerr Hawe), and Permaseal (Ultradent).
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