The fermentation process parameters vary with a range of factors, such as temperature and the composition of the fermentation broth. In order for being used as important project and process monitoring tools, these parameters should be constantly recalculated. In this research, a fermentation model for fed-batch reaction mode is presented, and experimental data are used for showing computation methodologies for recalculating the parameters.
Important properties in cementitious materials, such as concrete, are related to the presence of additives that influence the rigidity and the physical and chemical resistances. For the evaluation of the additive effectiveness, known as pozzolanic activity, a simple procedure, the Chapelle test, is commonly used, and it essentially consists in a reaction between the additive with calcium oxide in aqueous medium. However, such procedure presents limitations in terms of processing time and lack of information regarding the reactions kinetics. In this sense, a simple method based on the kinetic and thermodynamic principles of chemical reactions is proposed, which can be performed using conventional electronic pH sensors. The study provides an alternative methodology with many advantages over the traditional procedure, such as energy and time-savings, more robustness and more confidence. In this paper, three types of silica nanoparticles that can be used as low-cost additives were characterized in relation to their morphology and crystallinity by XRD and SEM, the particles average diameters were obtained and the particles were used for studying the chemical process that takes place during the Chapelle test. Results and the semi-empirical analysis provided strong evidence that the process is an acid-base 1:1 reaction and it was verified that the mean reaction times varied from 64 to 195 min. It is a remarkable result, since the proposed analysis can be performed with simple, fast and low-cost instrumentation and needs only a worksheet software, whereas the Chapelle test takes 16 hours and provides no dynamic information. Besides the limitation that the methodology is not able to quantify and to elucidate the effects of the specific surface area of the particles, which needs a complete BET study, the research provides a significant contribution for the understanding of the pozzolanic process, of great importance in both concrete and ceramic research.
Bioreactors are employed in several industries, such as pharmaceutics, energy, biomedic and food. To ensure the proper operation of these bioreactors, Enzyme-Linked Immunosorbent Assay (ELISA) and High-Performance Liquid Chromatography (HPLC) systems are commonly used. Although ELISA and HPLC provide very precise results, they are incapable of real-time monitoring and present high operational costs. Given this context, in this work, we discuss the technical and economic viability of implementing fiber optics-based monitoring systems in lieu of traditional ELISA and HPLC systems. We selected fed-batch ethanol fermentative systems for our analysis, as the fed-batch mode is not only prevalent in different fermentative industries, but ethanol production represents a major sector of the Brazilian economy, with annual production in excess of 35 billion liters. Then, a simple fiber sensing system for measuring the refractive index of the fermentation broth, capable of real-time monitoring the fermentation process, is proposed and the advantages of the real-time process control are discussed. Afterward, we present the long-term economic gains of implementing such a system. We estimate that, by using readily commercially available components, the typical Brazilian ethanol plants will see a return for their investment in a time as short as 50 days, with a 5-year Internal Rate of Return (IRR) of 742%/year by setting up a fiber-optic monitoring system over HPLC. With the provided list of components, these numbers can be easily adjusted for industries worldwide, providing incredibly attractive economic prospects.
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