Background: Novel psychoactive substances (NPS) are compounds of natural and synthetic origin, similar to traditional drugs of abuse. NPS are involved in a contemporary trend whose origin lies in a thinner balance between legitimate therapeutic drug research and legislative control. The contemporary NPS trend resulted from the replacement of MDMA by synthetic cathinones in ‘ecstasy’ during the 2000s. The most common NPS are synthetic cannabinoids and synthetic cathinones. Interestingly, during the last 50 years, these two classes of NPS have been the object of scientific research for a set of health conditions. Methods: Searches were conducted in the online database PubMed using boolean equations. Results: Synthetic cannabinoids displayed protective and therapeutic effects for inflammatory, neurodegenerative and oncologic pathologies, activating the immune system and reducing inflammation. Synthetic cathinones act similarly to amphetamine-type stimulants and can be used for depression and chronic fatigue. Conclusions: Despite the scientific advances in this field of research, pharmacological application of NPS is being jeopardized by fatalities associated with their recreational use. This review addresses the scientific achievements of these two classes of NPS and the toxicological data, ending with a reflection on Illicit and NPS control frames.
The manufacturing of automotive components using aluminium metal matrix composites (Al-MMCs) is progressively gaining a relevant place in the automotive industry. Due to the increasing competition in the automobile sector, there is a great need to supply efficient, stable, and high-quality products. Generally, following automotive standards is voluntary, which means that businesses and other organizations are not legally obliged to apply them. Nevertheless, in certain cases standards may facilitate compliance with legal requirements, such as those contained in European directives and regulations. IATF 16949:2016 is the current version of the IATF 16949 Standard and outlines the requirements an organization must maintain in their quality system for IATF 16949 certification. This new application of manufacturing Al-MMCs requires additional procedures to guarantee the quality of the components manufactured. Because the manufacturing process may generate various defects, such as cracks, voids, lack of fusion, inclusions, porosities, and other metallurgical aspects, non-destructive testing (NDT) techniques should be used for guaranteeing the quality of the components manufactured. The development of reliable NDT methods for aluminium metal matrix composite parts is thus a major challenge. This aspect is related to how NDT procedures need to be optimised or developed to address the singular structures of the processes, such as complex geometry, anisotropic material properties, special internal structures, and the presence of nanoparticles. The main objective of this work is to summarize and present the relevant potential of different NDT techniques used in quality control of manufactured Al-MMC components in the automotive industry, to be explorer in the European FLAMINGo project (Fabrication of Lightweight Aluminium Metal Matrix Composites and Validation in Green Vehicles). This study is very significant because the NDT techniques present different probabilities of detection of the defects, principally of the microdefects.
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