The majority of the subjects wanted to change to the new Harmony processor because of a better understanding in everyday life, handling, and improved battery-life time.
In all subgroups, an improvement of speech perception can be observed over time. The current patient group showed significant better performing results than those of the first group.
Current steering seems to have the potential to improve both understanding in adverse listening situations and frequency resolution. However, the optimal implementation needs further investigation.
Two-component systems (TCS) are short signalling pathways generally occurring in prokaryotes. They frequently regulate prokaryotic stimulus responses and thus are also of interest for engineering in biotechnology and synthetic biology. The aim of this study is to better understand and describe rewiring of TCS while investigating different evolutionary scenarios. Based on large-scale screens of TCS in different organisms, this study gives detailed data, concrete alignments, and structure analysis on three general modification scenarios, where TCS were rewired for new responses and functions: (i) exchanges in the sequence within single TCS domains, (ii) exchange of whole TCS domains; (iii) addition of new components modulating TCS function. As a result, the replacement of stimulus and promotor cassettes to rewire TCS is well defined exploiting the alignments given here. The diverged TCS examples are non-trivial and the design is challenging. Designed connector proteins may also be useful to modify TCS in selected cases.
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