Introduction. MicroRNA are small RNA molecules about 22 nucleotides long that do not encode proteins. Their function is to change the expression of proteins by attaching to their mRNA. They participate in various biological processes and pathogenesis of many diseases, including cancer. MicroRNA-26a-5p (miR-26a-5p) takes part in developing many disease entities and may become a potential therapeutic agent. Objective. The article aims to present the current knowledge on miR-26a-5p and consider the possible therapeutic use of this molecule. State of knowledge. Many studies on cell lines and model organisms indicate the suppressive function of miR-26a-5p in such neoplasms as breast cancer, pancreatic cancer, prostate cancer, thyroid cancer, or acute myeloid leukemia. In turn, in osteosarcoma cells, miR-26a-5p has an oncogenic character. miR-26a-5p is also associated with other diseases. Many authors have shown that this molecule is related to such entities as rheumatoid arthritis, osteoarthritis, preeclampsia, myocardial injury, or diabetic nephropathy. Conclusions. Understanding the functions of miR-26a-5p and its participation in human diseases' pathogenesis gives the possibility of the therapeutic use of this molecule in the future. However, knowledge of this subject is still limited. Further research to assess the efficacy and safety of the therapeutic use of miR-26a-5p is mandatory.
Tuberculosis (TB) is still a common infectious disease worldwide. In 2018, seven million new cases of TB were reported to the World Health Organization. The diagnosis of TB in children is difficult due to non-characteristic symptoms. A 14-year-old girl presented to a general practitioner due to coughing and general weakness for three weeks. Physical examination revealed a reduction in vesicular murmur over a significant area of the right lung, and chest X-ray showed extensive densities in the right lung. After several days of hospitalisation and antibiotic therapy for bacterial pneumonia, the girl was diagnosed with TB. A treatment plan was applied for six months. Radiological and clinical improvement was observed after the therapy. A detailed history, determining contact with the TB patient, physical examination, results of additional tests, and broad-spectrum antibiotics response are essential for diagnosis.
Cystic fibrosis is a monogenic disease caused by a mutation in the CFTR gene. The classic presentation of the disease includes chronic bronchopulmonary symptoms. However, abnormalities in this gene may also be manifested by other phenotypes, so-called CFTR-related disorders. This is a group of entities including disseminated bronchiectasis, congenital bilateral absence of vas deferens, and chronic pancreatitis. In this article, we present a family with a rare F1052V mutation and a polymorphic variant of IVS-5T+11TG. No classical form of the disease was observed in any of the persons affected by the above changes. Results of special investigations are also not typical, which hinders unequivocal diagnosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.