Original sin is not life but it is a part of life. It establishes psychological, mental and physical health. Statistics reveal several deaths of pregnant mothers, ectopic pregnancy, child deaths or original sin related diseases, apart from lethal consequences which is out of the scope of this article. Use of contraceptive methods may be beneficial in several circumstances avoiding unwanted pregnancies. A few television channels were scrolling the various contraceptive methods and educating the citizens for a good health perspective. The objective of this review is not only to enlighten the various contraceptive methods but also in knowing their failure level methods and some unique evaluation methods that can be included in Schedule R of the Drugs and Cosmetics Act, 1940 so as to append the quality attributes with in-vitro and in-vivo original sin correlated models. The review illustrates role of researchers/pharmacist/medical professionals in problem solving skills and is also expected to answer the general questions experienced and witnessed by the author relating to original sin including gender sensitization. In India, several national level bodies also insist for academic accreditations the contributions relating to gender sensitization and the article meets criteria as well. If the author as a common man sends a sample for current products for assessing abstract attributes, does Central Drugs Laboratory can?, a thought in this direction is needed which in turn indicates role of questionnaires/instruments in the Drugs and Cosmetics Act, 1940 and Rules 1945. Does a need of a statutory warning for original sin products is necessary, a question is raised and a review by persons skilled in art is proposed. The article illustrates either side to the context. The article also helps to overcome barriers from society, professional point of view relating to original sin related research either at the pre-clinical or at the clinical levels.
In the current study, a fundamental approach is used to establish operation procedure, for a hand operated double cone blender. Initially, assuming for a potent drug, where in, the strength of the drug is very less in the final dosage form, a one percent concentration of potassium permanganate with respect to final one kilogram of blended powder using starch as diluent was planned. With a kind of geometric progression method, at a rate of 10 rotations per minute, the final outcome of the uniform distribution of the potassium permanganate was found to be for at least for fourteen hours of rotations, leading to concentration range of potassium permanganate 0.08 ± 0.025 mg per mg of final blended powder.
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