Background: patients undergoing maintenance heamodialysis (HD) have a progressively loss of residual renal function (RRF), Short-term morbidity and mortality are significantly higher in patients lost RRF,and these patients frequently die before the development of long-term complications of dialysis. HD patients without preserved RRF have greater hospitalization rate, more significant malnutrition and health related quality of life. Aim: the aim of the present study was to assess impact of RRF on QoL in chronic HD patients and to study clinical and laboratory characteristics of these patients. Patients and Methods: this cross sectional study was carried out on 40 adult clinical stable regular HD Patients. They were divided into 2 groups according to the presence or absence of RRF.Group 1 included 20 HD patients with RRF (defined as urine volume >200 ml/24 h) and group 2 included 20 patients without RRF (defined as urine volume <200 ml/24 h). Results: patients with preserved RRF had a positive significant correlation between QoL scores, male gender ,younger age, employment, higher BMI (p=0.006), higher hemoglobin (p=0.036), higher predialysis serum creatinine (p=0.033), less complication during HD sessions hypotenstion (p=0.003), hypertenstion(p=0.003), vomiting (p=0.017), cramps(p=0.010)and Less use of Phosphate binders and Erythropoietin dose (p=0.020). Conclusion: HD patients with preserved RRF had better QoL scores compared to patients without RRF.Efforts to preserve RRF in HD patients could improve outcomes and should be encouraged.