The present study designed to evaluate the healing power of platelet-rich fibrin (PRF) in terms of pain control and mucosal repair. A randomised, controlled, pilot clinical trial was conducted on 16 patients randomly distributed with 1:1 allocation ratio into two groups. The treatment group received PRF minced and mixed with orabase and the control group received clobetasol propionate 0.05% mixed with orabase. Pain reduction was evaluated as primary outcome along with mucositis healing as secondary outcome. A statistically significant difference in pain reduction was observed between the two groups (p ≤ 0.05). The clinical results at Day 7 has shown that PRF group had 100% pain reduction while, CP group had 32.5% reduction from base line.PRF offered superior clinical results providing rapid pain alleviation and accelerated ulcer healing compared to corticosteroids. K E Y W O R D S benign mucous membrane pemphigoid, clobetasol propionate, oral ulcers, pemphigus vulgaris, platelet-rich fibrin, Stevens-Johnson syndrome 1 | INTRODUCTION Long standing oral ulcers that fail to respond to classical steroid therapy is a clinical problem that needs applicable intervention. A good example of the long standing ulcers is represented by blistering skin diseases. These are immune mediated diseases associated with oral mucositis and ulceration. Despite being immune mediated, each has
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