Background and Aim: Sarcocephalus latifolius is a medicinal plant commonly used in traditional medicine to treat various diseases. The aim of the present study is to evaluate the hepatoprotective activity of Sarcocephalus latifolius fruits aqueous extract against paracetamol-induced liver damage in rats. Material and Methods: Aqueous extract of Sarcocephalus latifolius fruits at doses of 100, 250 and 500 mg/kg were administered orally to rats with paracetamol-induced hepatotoxicity (1 g/kg). The treatment with the extract and paracetamol lasted 7 days. Silymarin (50 mg/kg) was given as reference control. All tested drugs were administered orally. Results: Our results show that the Sarcocephalus latifolius fruits extract induced a significant reduction (p < 0.05) of serum enzymes alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), alkaline phosphatase (PAL) and total bilirubin (TB). Then, the extract at the dose of 500 mg/kg showed a better protection (p < 0.001) of hepatocytes with a percentage of protection of 43.59% ± 2.03%; 59.43% ± 4.12%; 73.29% ± 5.72% and 62.55% ± 7.48% for ALAT, ASAT, PAL and TB, respectively. The histology of livers exposed to paracetamol shows an inflammation of the hepatocytes. In addition, there was a significant alteration of the liver parenchyma. The 500 mg/kg extract showed a resorption of the inflammation. Histopathological examination showed that the extract regenerated paracetamol-induced liver damage. Conclusion: Aqueous extract of Sarcocephalus latifolius fruits has hepatoprotective activity against paracetamol-induced hepatotoxicity in rats. But it would be important to evaluate the activity of aqueous extract of Sarcocephalus latifolius
Small ruminants are an important lever for livestock production in Burkina Faso. With a numerically important livestock population, small ruminants contribute to the fight against poverty and participate greatly in the country's economy. Despite its importance, the development of small ruminant breeding is strongly hindered by parasitic diseases due to gastrointestinal nematodes. The appearance of parasite resistance to anthelmintic molecules makes the treatment of gastrointestinal parasitosis more and more problematic. In order to provide rural farmers with an effective and accessible biological alternative, C. sesamoïdes whole plant powder in vivo anthelmintic efficacy was tested on mossi sheep artificially infested. Mossi sheep was artificially infested with 3200 L3 larvae of H. contortus 30 days before the beginning of the experiment. Two (2) treated batches of 6 sheep each received respectively 14g/kg of body weight and 7g/kg of body weight while one negative control batch of 6 sheep without treatment and one positive batch of 6 sheep treated with levamisole were constituted during the 21 days of experimentation. The Fecal Eggs Count (FEC) reduction rate was high during treatment and reached 87.08% and 74.91% at D21 respectively for the dose of 14g/kg body weight and 7g/kg body weight. Statistical analysis revealed no significant difference between the two doses tested and between the two doses and the positive control, whereas the difference was significant (P<0.05) compared to the negative control. The animal' weight evolution was not significant (P>0.05) compared to the negative control. The mean hematocrit level varied between D0 (27.66) and D21 (30.5) for the 14g/kg body weight dose while that of the animals treated with the 7g/kg body weight dose decreased slightly between D0 (27.33) and D21 (26.66). Biochemical blood tests show no suspicion of hepatic and renal impairment. Thus, C. sesamoïdes could be used as an alternative for the treatment of small ruminant's gastrointestinal nematodes in the form of whole plant powder in Burkina Faso.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.